ArticleFrontiers in endocrinology2025
The J-shaped relationship between serum osmolality and all-cause mortality in critically ill patients with myocardial infarction: a retrospective cohort study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The U-shaped association between serum osmolality and 28-day mortality in patients with acute respiratory failure: a retrospective cohort study using the MIMIC-IV database.Journal of thoracic disease · 2026Article
- Trajectory of serum osmolality changes and 28-day mortality risk in patients with sepsis-associated delirium based on the MIMIC-IV database.Scientific reports · 2025Article
- Serum Osmolality and Stroke Mortality in the ICU: A U-Shaped Risk Pattern and Its Clinical Implications.Journal of clinical medicine · 2025Article
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6 authors.
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Abstract
Background: Serum osmolality (SOSM) is an indicator of hydration status and is associated with the prognosis of various cardiovascular diseases. This study investigated the association between SOSM and all-cause mortality in critically ill patients with myocardial infarction (MI). Methods: This retrospective cohort study utilized data from the Medical Information for Intensive Care-IV (MIMIC-IV) database, including critically ill patients with a primary diagnosis of MI. Patients were categorized into tertile groups based on the SOSM levels. Kaplan-Meier (K-M) survival analysis, multiple Cox regression models, restricted cubic spline (RCS) analysis, and threshold effect analysis were used to investigate the nonlinear relationship between all-cause mortality in critically ill patients with MI and SOSM. Results: A total of 5354 patients with MI were included. K-M survival analysis showed that the survival rate of the high SOSM group was significantly lower than that of the other groups, which was consistent with the results after IPTW correction (log-rank Conclusions: This study revealed a J-shaped relationship between SOSM and all-cause mortality in critically ill MI patients, suggesting its potential as a prognostic marker for risk stratification.
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