Evidence map›Paper›PMID 40191075›Full record

ArticleFrontiers in neuroscience2025

The effect of vagus nerve stimulation on heart rate and respiration rate and their impact on seizure susceptibility in anaesthetized rats under pentylenetetrazol.

Javier Chávez Cerda, Elena Acedo Reina, Ayse S Dereli, Louis Vande Perre, Romain Raffoul, Maxime Verstraeten, Michel-Antony Ngan Yamb, Enrique Germany Morrison, Elise Collard, Auriane Apaire and 5 more

Abstract read
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In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Javier Chávez CerdaBio-, Electro-and Mechanical-Systems (BEAMS), Université Libre de Brussels, Brussels, Belgium.
Elena Acedo ReinaInstitute of Neurosciences (IoNS), Université Catholique de Louvain, Brussels, Belgium.
Ayse S DereliInstitute of Neurosciences (IoNS), Université Catholique de Louvain, Brussels, Belgium.
Louis Vande PerreBio-, Electro-and Mechanical-Systems (BEAMS), Université Libre de Brussels, Brussels, Belgium.
Romain RaffoulBio-, Electro-and Mechanical-Systems (BEAMS), Université Libre de Brussels, Brussels, Belgium.
Maxime VerstraetenBio-, Electro-and Mechanical-Systems (BEAMS), Université Libre de Brussels, Brussels, Belgium.
Michel-Antony Ngan YambBio-, Electro-and Mechanical-Systems (BEAMS), Université Libre de Brussels, Brussels, Belgium.
Enrique Germany MorrisonInstitute of Neurosciences (IoNS), Université Catholique de Louvain, Brussels, Belgium.
Elise CollardInstitute of Neurosciences (IoNS), Université Catholique de Louvain, Brussels, Belgium.
Auriane ApaireInstitute of Neurosciences (IoNS), Université Catholique de Louvain, Brussels, Belgium.
Pascal DoguetBio-, Electro-and Mechanical-Systems (BEAMS), Université Libre de Brussels, Brussels, Belgium.
Jérôme GarnierSynergia Medical SA, Mont-Saint-Guibert, Belgium.
Jean DelbekeInstitute of Neurosciences (IoNS), Université Catholique de Louvain, Brussels, Belgium.
Riëm El TahryInstitute of Neurosciences (IoNS), Université Catholique de Louvain, Brussels, Belgium.
Antoine NonclercqBio-, Electro-and Mechanical-Systems (BEAMS), Université Libre de Brussels, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the proven efficacy of vagus nerve stimulation (VNS) in seizure control, its precise mechanism of action remains unclear. VNS is known to impact the cardiorespiratory system. In this study, we explored the effects of standard and breathing-synchronized VNS on heart and respiratory rates in anesthetized epileptic rats, as well as their impact on seizure susceptibility. Seizures were induced in rats by intravenous pentylenetetrazol (PTZ) infusion. Three animal groups (

Indexed as

autonomic systemheart raterespiration rateseizure susceptibilityvagus nerve stimulation

Identifiers

PMID40191075
PMCPMC11968678

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.