Evidence map›Paper›PMID 40191998›Full record

ArticleeLife2025

Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice.

Jenny Chen, Phoebe R Richardson, Christopher Kirby, Sean R Eddy, Hopi E Hoekstra

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. The molecular evolution of vertebrate organs.Nature ecology & evolution · 2026
    Review
  2. Organization and evolution of sex-biased gene expression inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jenny ChenDepartment of Molecular & Cellular Biology, Harvard University, Cambridge, United States.ORCID https://orcid.org/0000-0002-6664-2597
Phoebe R RichardsonDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.ORCID https://orcid.org/0009-0008-5650-1556
Christopher KirbyDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.ORCID https://orcid.org/0000-0001-7292-9044
Sean R EddyDepartment of Molecular & Cellular Biology, Harvard University, Cambridge, United States.ORCID https://orcid.org/0000-0001-6676-4706
Hopi E HoekstraDepartment of Molecular & Cellular Biology, Harvard University, Cambridge, United States.ORCID https://orcid.org/0000-0003-1431-1769

Funding

The genetic control of neuronal number and behaviorK99GM146243 · NIGMS · HARVARD UNIVERSITY · PI CHEN, JENNIFER · 2022 to 2023
$216k
NIGMS NIH HHS K99 GM146243NIH HHS GM146243-01
6 · The paper itself

Abstract

Genetic variation is known to contribute to the variation of animal social behavior, but the molecular mechanisms that lead to behavioral differences are still not fully understood. Here, we investigate the cellular evolution of the hypothalamic preoptic area (POA), a brain region that plays a critical role in social behavior, across two sister species of deer mice (

Indexed as

Behavior, AnimalBiological EvolutionPeromyscusPreoptic AreaAnimalsFemaleMaleSex CharacteristicsSocial Behaviorevolutionary biologyneurosciencePeromyscusperomyscus maniculatusperomyscus polionotuspreoptic areasingle-nucleus RNA-sequencingsocial behavior

Identifiers

PMID40191998
PMCPMC11975375

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.