Evidence map›Paper›PMID 40192921›Full record

ReviewCurrent osteoporosis reports2025

Potential of Kefir-Derived Peptides, Probiotics, and Exopolysaccharides for Osteoporosis Management.

Jen-Chieh Lai, Gary Ro-Lin Chang, Min-Yu Tu, Abdulkadir Cidem, I-Chien Chen, Chuan-Mu Chen

Registry-linked trialAbstract readReview
In one paragraph

Review in Current osteoporosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07166458 (Fuctional Assessment of Kefir Fermented Milk on the Improvement of Osteoporosis Combined With Fracture Patient), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07166458 nacompletednot on this map

Fuctional Assessment of Kefir Fermented Milk on the Improvement of Osteoporosis Combined With Fracture Patient

TypeinterventionalSponsorJen-Chieh LaiRan2020 to 2025Enrolled30ConditionsBone FracturesArmsKefir Peptide, Standard Care (in control arm)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Commentary: Lactylation-related geneFrontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jen-Chieh LaiDepartment of Life Sciences, Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, 402, Taiwan.
Gary Ro-Lin ChangDepartment of Life Sciences, Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, 402, Taiwan.
Min-Yu TuDepartment of Life Sciences, Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, 402, Taiwan.
Abdulkadir CidemDepartment of Life Sciences, Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, 402, Taiwan.
I-Chien ChenDepartment of Life Sciences, Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, 402, Taiwan.
Chuan-Mu ChenDepartment of Life Sciences, Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, 402, Taiwan. chchen1@dragon.nchu.edu.tw.

Funding

Ministry of Education in Taiwan MOE-113-S-0023-ANational Science and Technology Council of Taiwan NSTC-113-2313-B-005-007-MY3
6 · The paper itself

Abstract

purpose of reviewOsteoporosis is a prevalent skeletal disorder in postmenopausal women and older adults. Kefir has gained attention for its potent antioxidative, anti-inflammatory, and immunomodulatory properties. This review consolidates findings on kefir-derived peptides' interventions in osteoporosis models and evaluates the therapeutic potential of kefir components in preventing osteoporosis, thereby enhancing its application in clinical nutrition strategies for osteoporosis management. RECENT

findingsKefir-derived peptides exhibit osteoprotective potential in various animal models of osteoporosis, in which several antioxidative and ACE-inhibitory peptides have been shown to promote osteoblast differentiation and mineralization. In addition, emerging evidence supports the role of kefir-derived probiotics and exopolysaccharides (kefiran) in mitigating bone loss. Kefir holds significant promise in the management of osteoporosis due to its unique composition of bioactive components promoting bone health. While research is still in its early stages, evidence suggests kefir's potential as a natural approach to osteoporosis prevention and management.

Indexed as

KefirOsteoporosisPeptidesPolysaccharidesProbioticsAnimalsAntioxidantsHumansAntioxidantsPeptidesPolysaccharidesBioactive peptidesExopolysaccharidesKefirOsteoporosisProbiotics

Identifiers

PMID40192921
PMCPMC11976759

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.