Evidence map›Paper›PMID 40193015›Full record

ArticleCardiovascular toxicology2025

MiR214-3p Ameliorates Diabetic Cardiomyopathy by Inhibiting Ferroptosis.

Peng Chen, Xiaohui Huang, Weixing Wen, Yue Cao, Weiwen Li, Guolin Huang, Yuli Huang, Yunzhao Hu, Tianyi Ma

Abstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng Chen *Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, 528308, Guangdong, China.
Xiaohui Huang *Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, 528308, Guangdong, China.
Weixing WenDepartment of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, 528308, Guangdong, China.
Yue CaoDepartment of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, 528308, Guangdong, China.
Weiwen LiDepartment of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, 528308, Guangdong, China.
Guolin HuangDepartment of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, 528308, Guangdong, China.
Yuli HuangDepartment of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, 528308, Guangdong, China. hyuli821@smu.edu.cn.
Yunzhao HuDepartment of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, 528308, Guangdong, China. huyunzhao4406@163.com.
Tianyi MaDepartment of Cardiology, Haikou People's Hospital/Central South University Xiangya School of Medicine Affiliated Haikou Hospital, No. 43, Renmin Avenue, Haikou, 570208, Hainan, China. selena_matianyi@163.com.

Funding

Natural Science Foundation of Hainan 821QN425Scientific Research Start Plan of Shunde Hospital, Southern Medical University SRSP2022012Scientific Research Start Plan of Shunde Hospital, Southern Medical University SRSP2022016the National Natural Science Foundation of China No.: 82270384
6 · The paper itself

Abstract

Ferroptosis is involved in the pathogenesis of diabetic cardiomyopathy (DCM). It has been shown that miR214-3p regulates ferroptosis, but no studies have shown a relationship between miR214-3p and DCM. This study induced glucolipotoxicity cardiomyocytes by treating HL-1 with high glucose and palmitic acid. Under these conditions, intracellular proteins TfR1 and FTH1, involved in Fe

Indexed as

Diabetic CardiomyopathiesFerroptosisMicroRNAsMyocytes, CardiacAnimalsCell LineCoenzyme A LigasesCyclooxygenase 2Disease Models, AnimalFibrosisGlucoseIronLipid PeroxidationMaleMiceMice, Inbred C57BLAcsl4 protein, mouseCoenzyme A LigasesCyclooxygenase 2Glucoseglutathione peroxidase 4, mouseIronMicroRNAsPalmitic AcidPhospholipid Hydroperoxide Glutathione PeroxidasePtgs2 protein, mouseDiabetic cardiomyopathyFerroptosisGPX4Lipid peroxidationMiR214-3p

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.