Evidence map›Paper›PMID 40193178›Full record

ArticleeLife2025

Synaptic cell adhesion molecule

Julieta Gomez-Frittelli, Gabrielle Frederique Devienne, Lee Travis, Melinda A Kyloh, Xin Duan, Tim J Hibberd, Nick J Spencer, John R Huguenard, Julia A Kaltschmidt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Unique properties of proximal and distal colon reflect distinct motor functions.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Julieta Gomez-FrittelliDepartment of Chemical Engineering, Stanford University, Stanford, United States.ORCID https://orcid.org/0000-0001-8859-9270
Gabrielle Frederique DevienneWu Tsai Neurosciences Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0000-0002-2204-8043
Lee TravisCollege of Medicine and Public Health, Flinders Health & Medical Research Institute, Flinders University, Adelaide, Australia.
Melinda A KylohCollege of Medicine and Public Health, Flinders Health & Medical Research Institute, Flinders University, Adelaide, Australia.
Xin DuanDepartment of Ophthalmology, School of Medicine, University of California San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0001-5260-8972
Tim J HibberdCollege of Medicine and Public Health, Flinders Health & Medical Research Institute, Flinders University, Adelaide, Australia.
Nick J SpencerCollege of Medicine and Public Health, Flinders Health & Medical Research Institute, Flinders University, Adelaide, Australia.ORCID https://orcid.org/0000-0003-2190-5303
John R HuguenardWu Tsai Neurosciences Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0000-0002-6950-1191
Julia A KaltschmidtWu Tsai Neurosciences Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0000-0002-2893-1793

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0M
Inhibitory Controls of Thalamic NeuronsR01NS034774 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 1996 to 2021
$5.5M
Mechanisms Underlying Type II Cadherin Guided Assembly of Retinal CircuitsR01EY030138 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Xin Duan · 2020 to 2026
$3.2M
Stanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020
$1.2M
Development and Patterning of the Enteric Nervous SystemR21HD110950 · NICHD · STANFORD UNIVERSITY · PI KALTSCHMIDT, JULIA ANNA · 2023 to 2023
$431k
Australian Research Council DP220100070National Health and Medical Research Council 1156416NEI NIH HHS R01 EY030138NIA NIH HHS P30 AG066515NICHD NIH HHS R21 HD110950NIGMS NIH HHS T32 GM120007NIGMS NIH HHS T32GM120007NIH HHS P30AG066515NIH HHS R01 EY030138NIH HHS R21 HD110950NINDS NIH HHS 5R01NS34774NINDS NIH HHS R01 NS034774
6 · The paper itself

Abstract

Intrinsic sensory neurons are an essential part of the enteric nervous system (ENS) and play a crucial role in gastrointestinal tract motility and digestion. Neuronal subtypes in the ENS have been distinguished by their electrophysiological properties, morphology, and expression of characteristic markers, notably neurotransmitters and neuropeptides. Here, we investigated synaptic cell adhesion molecules as novel cell-type markers in the ENS. Our work identifies two type II classic cadherins,

Indexed as

CadherinsColonEnteric Nervous SystemGastrointestinal MotilitySensory Receptor CellsAnimalsMiceCadherinscadherin-6colonic motor complexesenteric nervous systemmicemouseneurosciencesensory neuronssynaptic cell adhesion molecule

Identifiers

PMID40193178
PMCPMC11975370

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.