Evidence map›Paper›PMID 40193515›Full record

ReviewJournal of experimental psychology. Animal learning and cognition2025

The inside story: Interoceptive Pavlovian conditioning with the nicotine stimulus.

Scott T Barrett, Kathleen R McNealy, MacKenzie L Knabel, Rachel M Burrichter, Kaitlyn A Steck, Rick A Bevins

Abstract readReview
In one paragraph

Review in Journal of experimental psychology. Animal learning and cognition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Scott T BarrettUniversity of Nebraska-Lincoln, Department of Psychology.
Kathleen R McNealyUniversity of Nebraska-Lincoln, Department of Psychology.
MacKenzie L KnabelUniversity of Nebraska-Lincoln, Department of Psychology.
Rachel M BurrichterUniversity of Nebraska-Lincoln, Department of Psychology.
Kaitlyn A SteckUniversity of Nebraska-Lincoln, Department of Psychology.
Rick A BevinsUniversity of Nebraska-Lincoln, Department of Psychology.ORCID 0000-0002-2438-2264

Funding

Testing the Efficacy of Ibudilast to Attenuate Meth-seeking and Associated Synaptic Inflammation at the Synapse (TEAMS)P20GM130461 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI KIMBERLY A TYLER · 2019 to 2026
$20.6M
Interoceptive conditioning with nicotine: Changes in abuse liabilityR01DA046109 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI BEVINS, RICK A · 2018 to 2022
$1.8M
Understanding and mitigating exacerbated nicotine use resulting from Pavlovianinteroceptive conditioningR01DA057208 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI Rick A Bevins · 2023 to 2026
$1.4M
Pharmacological interventions to diminish nicotine associated respondingR01DA034389 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI BEVINS, RICK A · 2012 to 2016
$1.4M
Acquired Appetitive Properties of NicotineR01DA018114 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI BEVINS, RICK A · 2004 to 2010
$1.4M
Interplay between interoception, learning, and drug seekingR21DA039356 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BESHEER, JOYCE, BEVINS, RICK A · 2016 to 2017
$420k
Altering nicotine reward through conditioningR21DA023951 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI BEVINS, RICK A · 2008 to 2009
$339k
Contraceptive hormone impacts on the primary reinforcing and reward-enhancing effects of nicotineR36DA059867 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI MCNEALY, KATHLEEN ROBIN · 2024 to 2025
$107k
NIDA NIH HHS R01 DA018114NIDA NIH HHS R01 DA034389NIDA NIH HHS R01 DA046109NIDA NIH HHS R01 DA057208NIDA NIH HHS R21 DA023951NIDA NIH HHS R21 DA039356NIDA NIH HHS R36 DA059867NIGMS NIH HHS P20 GM130461
6 · The paper itself

Abstract

Pavlovian conditioning plays a crucial role in promoting well-being and supporting healthy behaviors but also contributes to the development of diseases and psychopathologies. Much of the basic and applied research on these conditioning processes has focused on external or exteroceptive cues (tone, spider, context, and brewery) as the conditioned stimulus (CS) or occasion setter. Considerably less empirical effort has been devoted to studying Pavlovian conditioning involving internal or interoceptive stimuli, such as indigestion, low blood sugar, back pain, or drug intoxication function as the CS or occasion setter. In this targeted review, we focus on our research on the interoceptive stimulus effects of nicotine. We summarize methods employing discriminated goal-tracking that have been refined over the years to investigate how the function of the nicotine stimulus changes with excitatory or inhibitory conditioning protocols. That research provides substantive evidence indicating that what is known about Pavlovian conditioning with exteroceptive stimuli generally holds for the nicotine stimulus-extinction, CS salience, generalization, overshadowing, blocking, conditioned inhibition, devaluation, and overexpectation. Extension of the interoceptive conditioning methodology to include intravenous nicotine as a stimulus found that the nicotine stimulus acquires additional reinforcing value when previously paired with an appetitive outcome. In closing this review, we highlight notable gaps in the literature and discuss potential directions for research and conceptual development. Ultimately, we hope to encourage others to consider the intersection of interoception and Pavlovian conditioning in their area of scientific inquiry. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Indexed as

Conditioning, ClassicalInteroceptionNicotineNicotinic AgonistsAnimalsHumansNicotineNicotinic Agonists

Identifiers

PMID40193515
PMCPMC11999299

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.