Observational studyMedicine2025
Predictive role of insulin resistance surrogates in gallstone disease.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A nomogram for estimating prevalent gallstone risk in patients with type 2 diabetes: development and validation in a multicenter cohort.BMC endocrine disorders · 2026Article
- The U-shaped association between the metabolic score for insulin resistance and incident gallstone disease: a population-based cohort study.Frontiers in endocrinology · 2026Article
- Insulin Resistance Across Cerebrovascular and Related Disorders: Mechanisms, Measurement, Genetics, and Clinical Implications.Neuropsychiatric disease and treatment · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Several studies have confirmed the association between insulin resistance (IR) surrogates and the risk of cardiovascular disease. This study aimed to investigate the correlation between 4 IR surrogates: triglyceride-glucose index (TyG), triglyceride-glucose index with waist circumference (TyG-WC), triglyceride-glucose index with body mass index (TyG-BMI), and triglycerides/high-density lipoprotein cholesterol ratio, and the risk of gallstone disease. This retrospective cross-sectional study involved a total of 19,696 participants who were divided into gallstone and non-gallstone groups based on ultrasound findings. Biochemical parameters and ultrasound results were collected and statistically analyzed. Nonparametric U test, Chi-square test, and subgroup analysis were used to examine the differences in expression of the 4 IR surrogates between the 2 groups. Logistic regression models and receiver operating characteristic curves were employed to evaluate the relationships and predictive ability of the 4 surrogates for gallstone disease. The levels of the 4 surrogates of IR were significantly higher in individuals with gallstone disease (GSD) compared to those without GSD (P < .001). After adjusting for age, gender, and personal medical history, TyG-WC and TyG-BMI emerged as significant predictors of gallstones in both genders. The predictive ability of these IR surrogates was stronger for gallstone disease in females than in males. In females, the area under the curve for TyG-WC and TyG-BMI were 0.683 and 0.629, respectively, while for males, these values were 0.544 and 0.528. When age was included with TyG-WC and TyG-BMI to predict GSD, the area under the curve values increased to 0.734 and 0.733 for females, and 0.684 and 0.682 for males. The study found that TyG-WC and TyG-BMI were identified as independent risk factors for the prevalence of GSD. Additionally, combined with age, TyG-WC and TyG-BMI showed good predictive value for the prevalence of GSD in females.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.