Evidence mapPaperPMID 40194922Full record

ArticleAngewandte Chemie (International ed. in English)2025

Beyond Structure: Methylation Fine-Tunes Stability and Folding Kinetics of bcl2Mid G-Quadruplex.

Nataša Medved, Mirko Cevec, Uroš Javornik, Jurij Lah, San Hadži, Janez Plavec

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nataša MedvedSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, Ljubljana, Slovenia.
Mirko CevecSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, Ljubljana, Slovenia.
Uroš JavornikSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, Ljubljana, Slovenia.
Jurij LahFaculty of Chemistry and Chemical Technology, Večna pot 113, Ljubljana, Slovenia.
San HadžiFaculty of Chemistry and Chemical Technology, Večna pot 113, Ljubljana, Slovenia.
Janez PlavecSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, Ljubljana, Slovenia.

Funding

Slovenian Research and Innovation Agency J1-60019Slovenian Research and Innovation Agency P1-0242 P1-0201
6 · The paper itself

Abstract

Cytosine methylation, a key epigenetic modification in the regulation of gene expression, raises intriguing questions about its role in the formation and thermodynamic stability of G-quadruplex (G4) structures. We investigated the impact of the 5-methylcytosine residue (C

Indexed as

G-QuadruplexesProto-Oncogene Proteins c-bcl-25-MethylcytosineDNA MethylationHumansKineticsThermodynamics5-MethylcytosineProto-Oncogene Proteins c-bcl-2Differential scanning calorimetryDNA methylationG‐quadruplexesKineticsNMR spectroscopy

Identifiers

PMID40194922
PMCPMC12144886

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.