ArticleJournal of the American Heart Association2025
Mediation of Time-Related Blood Pressure Variability on Intensive Blood Pressure Lowering and Functional Outcomes Post Endovascular Therapy: A Post Hoc Analysis of the OPTIMAL-BP Trial.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Mid-term systolic BP variability beyond 24 h after successful recanalization predicts poor outcomes following ischemic stroke.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
Corrections and comments
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Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated whether the association between blood pressure (BP) management in patients with successful reperfusion following endovascular therapy (EVT) and functional outcomes is mediated by BP variability parameters. METHODS AND
resultsThis is a post hoc analysis of the OPTIMAL-BP (Outcome in Patients Treated With Intra-Arterial Thrombectomy-Optimal Blood Pressure Control) trial, conducted at 19 centers in South Korea. The primary outcome was the 90-day functional outcome, assessed using the modified Rankin Scale. Multivariable logistic regression analysis was conducted for the association between BP variability and outcomes including 90-day modified Rankin Scale score, symptomatic intracranial hemorrhage, and final infarction volume. Mediation analysis was performed to evaluate the causal inference whether the relationship between intensive BP management and the 90-day modified Rankin Scale scoreis mediated by 24-hour BP variability parameters (time rate [TR], SD, coefficient of variation, and variability independent of the mean). Among various BP variability parameters, higher TR was associated with an unfavorable ordinal shift of the 90-day modified Rankin Scale score (adjusted odds ratio [aOR], 1.17 [95% CI, 1.04-1.32],
conclusionsTR mediated the relationship between intensive BP management and poor functional outcome in successfully reperfused patients with ischemic stroke by contributing to an increase in infarct volume. Efforts to modulate TR after EVT may be helpful in improving clinical outcomes.
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