Evidence map›Paper›PMID 40195258›Full record

ArticleDrug delivery and translational research2025

Novel injectable sodium alginate hydrogel developed for improved endometrial repair with human umbilical cord mesenchymal stem cells.

Yifan Li, Weimin Yin, Haiqing Dong, Rongxiang Wang, Lihua Sun, Yongyong Li, Jing Xie

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yifan Li *Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Weimin Yin *The Institute for Biomedical Engineering & Nano Science (Inano), Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Haiqing DongThe Institute for Biomedical Engineering & Nano Science (Inano), Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Rongxiang WangThe Center for Reproductive Medicine, Shanghai East Hospital, Tongji University, Shanghai, 200120, China.
Lihua SunThe Center for Reproductive Medicine, Shanghai East Hospital, Tongji University, Shanghai, 200120, China.
Yongyong LiThe Institute for Biomedical Engineering & Nano Science (Inano), Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. yongyong_li@tongji.edu.cn.
Jing XieFundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. jingxie@tongji.edu.cn.ORCID 0009-0002-1096-376X

Funding

Fundamental Research Funds for the Central Universities 22120240435National Key Research and Development Program of China 2018YFA0800100National Natural Science Foundation of China 31871490National Natural Science Foundation of China 32170800
6 · The paper itself

Abstract

This study presents a novel injectable sodium alginate hydrogel designed to enhanc stem cell therapy for endometrial regeneration. Using calcium gluconate as a crosslinking agent, we achieved improved homogeneity and injectability compared to traditional calcium chloride crosslinking. RGD modification further enhanced cell adhesion, proliferation, and differentiation in vitro, creating a bioactive scaffold for umbilical cord mesenchymal stem cells (UCMSCs) delivery. In a mouse model of endometrial injury, intrauterine transplantation of RGD-modified hydrogel encapsulating UCMSCs significantly improved endometrial thickness, reduced fibrosis, enhanced angiogenesis, and increased pregnancy rates compared to both untreated controls and UCMSCs alone. These results suggest that this injectable hydrogel system combined with stem cells holds significant promise for future applications in treating endometrial damage and improving reproductive outcomes in women.

Indexed as

AlginatesEndometriumHydrogelsMesenchymal Stem CellsMesenchymal Stem Cell TransplantationUmbilical CordAnimalsCalcium GluconateCell AdhesionCell DifferentiationCell ProliferationCells, CulturedFemaleGlucuronic AcidHexuronic AcidsHumansAlginatesarginyl-glycyl-aspartic acidCalcium GluconateGlucuronic AcidHexuronic AcidsHydrogelsOligopeptidesAlginate HydrogelEndometrial RegenerationInjectableReproduction.Stem Cell Therapy

Identifiers

PMID40195258

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.