Evidence map›Paper›PMID 40195303›Full record

ArticleSignal transduction and targeted therapy2025

Tripeptide DT-109 (Gly-Gly-Leu) attenuates atherosclerosis and vascular calcification in nonhuman primates.

Linying Jia, Pengxiang Qu, Yang Zhao, Liang Bai, Honghao Ren, Ao Cheng, Zeyao Ma, Cheng Ding, Yongjie Deng, Lingxuan Kong and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Linying Jia *Laboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Pengxiang Qu *Laboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.ORCID 0000-0001-7858-9124
Yang ZhaoDepartment of Internal Medicine, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-1428-5145
Liang BaiLaboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Honghao RenLaboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Ao ChengLaboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Zeyao MaLaboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Cheng DingLaboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Yongjie DengDepartment of Internal Medicine, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Lingxuan KongDepartment of Biostatistics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Ying ZhaoDepartment of Internal Medicine, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Oren RomDepartment of Internal Medicine, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Yajie ChenGuangdong Province Key Laboratory, Southern China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, Guangdong, 529000, China.
Naqash AlamLaboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Wenbin CaoLaboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Sixue ZhaiDepartment of Imaging, the Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China.ORCID 0009-0006-0602-1007
Zuowen ZhengSpring Biological Technology Development Co., Ltd, Fangchenggang, Guangxi, 538000, China.
Zhi HuDepartment of Cardiovascular Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Lu WangDepartment of Biostatistics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Yabing ChenDepartment of Pathology and Laboratory Medicine, Oregon Health & Science University; Research Department, Portland Veterans Affairs Medical Center, Portland, OR, 97239, USA.
Sihai ZhaoLaboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Jifeng ZhangDepartment of Internal Medicine, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-5161-4705
Jianglin FanGuangdong Province Key Laboratory, Southern China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, Guangdong, 529000, China. jianglin@yamanashi.ac.jp.
Y Eugene ChenDepartment of Internal Medicine, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. echenum@umich.edu.ORCID 0000-0003-2357-7825
Enqi LiuLaboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China. liuenqi@mail.xjtu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81970425
6 · The paper itself

Abstract

Advanced atherosclerotic lesions and vascular calcification substantially increase the risk of cardiovascular events. However, effective strategies for preventing or treating advanced atherosclerosis and calcification are currently lacking. This study investigated the efficacy of DT-109 (Gly-Gly-Leu) in attenuating atherosclerosis and calcification in nonhuman primates, exploring its broader therapeutic potential. In this study, twenty male cynomolgus monkeys were administered a cholesterol-rich diet ad libitum for 10 months. Then, the animals were treated either orally with DT-109 (150 mg/kg/day) or a vehicle (H

Indexed as

AtherosclerosisOligopeptidesVascular CalcificationAnimalsHumansMacaca fascicularisMaleMyocytes, Smooth MuscleOligopeptides

Identifiers

PMID40195303
PMCPMC11977015

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.