ArticleFrontiers in molecular neuroscience2025
The serum proteomic profile in patients with migraine.
Article in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Single-cell RNA-sequencing reveals cellular heterogeneity and identifies biomarkers for obstructive sleep apnea and migraine.Human genomics · 2026Article
- Extracellular Vesicles in Migraine: Biomarkers and Therapeutics.Molecular neurobiology · 2026Review
- Neuroimmune dysregulation and comorbidity mechanisms of major depressive disorder and migraine.BMC psychiatry · 2026Article
- Neuron-derived extracellular vesicles reflect adaptive neuronal responses to cortical spreading depolarization: a biomarker study for migraine.The journal of headache and pain · 2025Article
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4 authors.
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Abstract
Background: Migraine is a paroxysmal headache disorder, which seriously affects the patients' quality of life. However, the pathogenesis of migraine is not clear yet. Proteomics is an emerging technology for studying small molecules and protein components in biological systems. This study aimed to analyze the serum proteome of migraine patients and healthy controls and identify differentially expressed proteins, which could provide a reference for the study of biomarkers and pathophysiological mechanisms of migraine. Methods: Fasting venous blood was collected, and serum was separated. Liquid chromatography-mass spectrometry was used to detect the proteome of the two groups, and MaxQuant was used to analyze the protein profile and identify the differentially expressed proteins. Results: Twenty-seven migraine patients and 20 healthy people matching the age and sex ratio of the migraine group were collected. A total of 27 differentially expressed proteins were identified between migraine and control groups, which were mainly related to immune response, inflammation, glycolysis, lipid metabolism, neurotrophy and development, and so on. Subgroup analysis also identified several differentially expressed proteins between the migraine with aura and the migraine without aura groups and between the ictal and interictal migraine groups. Moreover, the signal pathways that may be related to migraine include the glycolysis/gluconeogenesis pathway and the hypoxia-inducible factor-1 signal pathway. Differentially expressed proteins are mainly distributed in the extracellular area. Related biological processes include complement activation, immunoglobulin receptor binding, and phagocytosis. Discussion: The research screened out several differentially expressed proteins of migraine patients, which may be potential biomarkers, but it still needs verification in further studies with larger sample sizes. Various proteins related to inflammation, immune response, and energy metabolism are differentially expressed between the migraine group and the control group, suggesting that the pathogenesis of migraine may be related to inflammation, immunity, and energy metabolism disorders. In the future, we can further explore the therapeutic targets of migraine in terms of these biological processes.
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