Evidence map›Paper›PMID 40196602›Full record

ArticlebioRxiv : the preprint server for biology2025

Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer's Dementia to Living Humans.

Yasser Iturria-Medina, Victoria N Poole, Andrea R Zammit, Lei Yu, Shinya Tasaki, Joon Hwan Hong, Katia de Paiva Lopes, Caio Batalha, Abdur Raquib Ridwan, Ricardo A Vialle and 18 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Yasser Iturria-MedinaNeurology and Neurosurgery Department, Montreal Neurological Institute, Montreal, Canada.ORCID 0000-0002-9345-0347
Victoria N PooleRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Andrea R ZammitRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Shinya TasakiRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Joon Hwan HongNeurology and Neurosurgery Department, Montreal Neurological Institute, Montreal, Canada.
Katia de Paiva LopesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Caio BatalhaInstituto de Assistência Médica ao Servidor Público Estadual, Sao Paulo, SP, Brazil.
Abdur Raquib RidwanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Ricardo A VialleRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Lazaro Sanchez-RodriguezNeurology and Neurosurgery Department, Montreal Neurological Institute, Montreal, Canada.
Maiya Rachel GeddesNeurology and Neurosurgery Department, Montreal Neurological Institute, Montreal, Canada.
Peter AbadirJohns Hopkins University School of Medicine, Baltimore, USA.
Eric OrtlundDepartment of Biochemistry at Emory University School of Medicine, Atlanta, USA.ORCID 0000-0001-8855-3029
Philip De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-8057-2505
Vilas MenonCenter for Translational & Computational Neuroimmunology, Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
Michal Schnaider BeeriKreiger Klein Alzheimer's Research Center, Brain Health Institute, Rutgers Health, NJ, USA.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0002-6426-2742
Yishai LevinIsrael National Center for Personalized Medicine at Weizmann Institute of Science, Rehovot, Israel.
David MorgensternIsrael National Center for Personalized Medicine at Weizmann Institute of Science, Rehovot, Israel.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Rima Kaddurah DaoukDuke University Medical Center, NC, USA.
Tony Wyss-CoraySchool of Medicine, Stanford University, CA, USA.ORCID 0000-0001-5893-0831
Nicholas T SeyfriedDepartment of Biochemistry at Emory University School of Medicine, Atlanta, USA.ORCID 0000-0002-4507-624X
Konstantinos ArfanakisRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, Montreal Neurological Institute-Hospital, Montreal, QC, Canada.ORCID 0000-0001-9116-1376
Yanling WangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0002-8589-4239
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Rush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7M
Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathologyRF1NS139975 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI ARFANAKIS, KONSTANTINOS, BLURTON-JONES, MATHEW MARK · 2024 to 2024
$5.4M
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaU01NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2023 to 2025
$3.5M
In-vivo MRI-based prediction of TDP43 pathology in agingR01AG064233 · NIA · ILLINOIS INSTITUTE OF TECHNOLOGY · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2019 to 2023
$3.3M
NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG064233NIA NIH HHS U01 AG061356NINDS NIH HHS RF1 NS139975NINDS NIH HHS U01 NS100599
6 · The paper itself

Abstract

Alzheimer's disease (AD) dementia is characterized by significant molecular and phenotypic heterogeneity, which confounds its mechanistic understanding, diagnosis, and effective treatment. In this study, we harness the most comprehensive dataset of paired

Identifiers

PMID40196602
PMCPMC11974700

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.