Evidence map›Paper›PMID 40197172›Full record

ArticleBMC genomics2025

Integrated analysis of tyrosine-induced MiRNA and mRNA expression profiles in melanocytes reveals the regulatory role of miR-1560-3p in melanin deposition in Xichuan black-bone chickens.

Zhiyuan Zhang, Pengwei Zhang, Fumin He, Yingdong Hou, Xiaowen Geng, Ruilong Xu, Ruiting Li, Yadong Tian, Wenting Li, Guirong Sun and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhiyuan Zhang *College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Pengwei Zhang *College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Fumin HeCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Yingdong HouCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Xiaowen GengCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Ruilong XuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Ruiting LiHenan University of Animal Husbandry and Economy, Zhengzhou, 450046, China.
Yadong TianCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Wenting LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Guirong SunCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Ruirui JiangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Xiaojun LiuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Ruili HanCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Guoxi LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Xiangtao KangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China.
Donghua LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, P. R. China. lidonghua6656@126.com.

Funding

the Scientific Studio of Zhongyuan Scholars 30601985the University Youth Innovation Fund 30501085The Youth Fund of the National Natural Science Fund project 32102540
6 · The paper itself

Abstract

backgroundTyrosine is a prerequisite for melanin biosynthesis and plays a crucial role in the growth and development of melanocytes, but the underlying mechanism is still unclear. In our previous research, we added 10

methodsIn this study, melanocytes from Xichuan black-bone chickens were used as research objects, 10

resultsWe found that tyrosine promoted the proliferation and migration of melanocytes, and expression profile analysis identified 57 differentially expressed mRNAs (DEGs) and 19 differentially expressed miRNAs (DEMs). Fifty miRNA‒mRNA target gene pairs were identified via coexpression network analysis of the DEGs and the DEMs that were predicted to target various genes. Notably, VIP gene was reported to be involved in the development and deposition of melanoma cells. The binding of VIP to miR-1560-3p was further validated by a dual-luciferase reporter assay. In addition, test confirmed that miR-1560-3p inhibited the proliferation and migration of melanocytes and reduced the tyrosinase content. In conclusion, we found that tyrosine may affects melanin deposition in Xichuan black-bone chickens by affecting the miR-1560-3p-VIP axis. The results of this study provide experimental evidence for elucidating the mechanism of tyrosine in melanin deposition in black-bone chickens, and may serve as a reference for future investigations.

Indexed as

ChickensMelaninsMelanocytesMicroRNAsRNA, MessengerTyrosineAnimalsCell MovementCell ProliferationGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksMelaninsMicroRNAsRNA, MessengerTyrosineMelanin depositionmiR-1560-3p-VIPTranscriptomic analysisTyrosine

Identifiers

PMID40197172
PMCPMC11974055

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.