ArticleBMC public health2025
Global trends and burdens of neglected tropical diseases and malaria from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Disability as a neglected outcome of neglected tropical diseases: A systematic review.PLoS neglected tropical diseases · 2026Pooled it
- Selective advantages, selective mismatches, chronic inflammation, obesity, and type 2 diabetes: a new hypothesis to explain the effects of natural selection on genetic variation at the ectodysplasin A receptor locus.BMJ open diabetes research & care · 2026Review
- Estimation of the global burden of tungiasis in endemic countries using a disability adjusted life-years modelling approach.BMC global and public health · 2026Article
- Development and validation of a national questionnaire assessing knowledge, attitudes, and practices on neglected tropical diseases among italian medical trainees.PLoS neglected tropical diseases · 2026Article
- Influence of climate variability and seasonal trends on malaria incidence in Dar es Salaam, Tanzania using generalized additive models.Epidemiology and infection · 2026Article
- Article
- Targeting of Leishmania proteins by β-Lapachone derivatives reveals a promising multitarget candidate.Archives of microbiology · 2026Article
- Trends and Burden of Human Rabies in Iran 2012-2021: A Cross-Sectional Study.Health science reports · 2026Article
- Malaria in the 21st Century: Global Disease Burden, Epidemiological Insights, and Strategic Control Approaches.Biology · 2026Review
- Diseases Caused by Parasites with Invertebrate Hosts in China: Burden and Trends of Leishmaniasis and Schistosomiasis.Pathogens (Basel, Switzerland) · 2026Article
- Knowledge, Attitudes, and Practices of Schoolchildren About Cutaneous Leishmaniasis in Dehloran City, Ilam Province, Southwest of Iran.Journal of community health · 2026Article
- Synthesis, characterisation and evaluation of polyethylene glycol-β-cyclodextrin-curcumin-zinc oxide nanoparticles for mosquitocidal, antibacterial and anticancer applications.Scientific reports · 2026Article
- Metabolomics in Infectious Diseases and Vaccine Response: Insights into Neglected Tropical and Non-Neglected Pathogens.Infectious disease reports · 2026Review
- Paradoxes of Elimination and Persistence: Neglected Tropical Diseases in Ecuador Compared to Latin America and the Caribbean.Journal of tropical medicine · 2026Review
- Global burden and trends of non-communicable diseases among children and adolescents from 1990 to 2021: an age-period-cohort and frontier analysis with projections to 2035.Frontiers in public health · 2026Article
- Neglected tropical diseases: recent trends and challenges associated with its rapid diagnosis and effective therapeutic strategies.Frontiers in pharmacology · 2026Review
- Optimization of Physicochemical Properties and ADME for 2,4-Substituted 1Journal of medicinal chemistry · 2025Article
- Global Epidemiology of Vector-Borne Parasitic Diseases: Burden, Trends, Disparities, and Forecasts (1990-2036).Pathogens (Basel, Switzerland) · 2025Article
- Rethinking malaria elimination: a perspective on challenges and solutions in Angola.Malaria journal · 2025Review
- Folic acid utilization and associated factors among pregnant women who attended public health facilities of illuababor zone, Southwest Ethiopia.Women's health (London, England)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeglected tropical diseases and malaria (NTDm) afflict the most disadvantaged communities, causing chronic and devastating illnesses. The purpose of this study was to investigate the epidemiological features of NTDm from 1990 to 2021 to provide essential information for policy choices to reduce the incidence of NTDm.
methodsThe Global Burden of Disease Study 2021 provided information on the incidence, mortality, prevalence, and disability-adjusted life-year (DALY) rates of NTDs and malaria from 1990 to 2021. Prevalence and trends were analysed globally as well as by region, sex, and age. The estimated annual percentage change (EAPC) was used to evaluate illness trends, and the connection between sociodemographic indicators (SDIs) and disease burden was investigated. To further examine the patterns and forecasts, the age-period-cohort (APC) and Bayesian age‒period‒cohort (BAPC) models were used. On the basis of the results of the analysis, the main risk factors affecting NTDm were explored in depth.
resultsIn 2021, the global NTDm age-standardized incidence rate increased by 24.12 (95% UI: -158.97-206.77) from 1990. The burden was highest in West and Central Sub-Saharan Africa, with dengue, malaria and rabies being particularly prominent. The incidence rates standardized by age, prevalence rates, mortality rates, and rates of disability-adjusted life years (DALYs) were primarily observed in children younger than five years and in regions with low SDIs. Analyses considering age, period, and cohort indicated that the burden of disease has diminished in populations born later. Forecasts suggest a minor rise in age-standardized incidence rates (ASIRs) from 2022 to 2035, whereas age-standardized prevalence rates (ASPRs), age-standardized mortality rates (ASMRs), and age-standardized disability-adjusted life year rates (ASDRs) are anticipated to decline. Major risk factors for NTDm include child and maternal malnutrition, child growth failure, child stunting and child underweight.
conclusionsThe burden of NTDm varies by region, age and sex. This is particularly the case in low-SDI regions. To reduce the global burden of NTDm, specific strategies such as strengthening health systems, fostering cross-sector collaboration, and enhancing community participation are essential. Integrated management requires a multisectoral approach that combines policy, health care, education, research, and community involvement to support sustainable development goals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.