Evidence map›Paper›PMID 40197181›Full record

ArticleCurrent molecular medicine2026

Enhancement of Platinum-based Drug Sensitivity in Ovarian Cancer Cells Through Hyperthermia-induced Activation of the TGF-β1/β-Catenin Signaling Pathway.

Xiaogang Lv, Wenjuan Wu, Gaoting Huang, Xiaowen Yao, Shirong Zeng, Yifeng Wang

Abstract read
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In one paragraph

Article in Current molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaogang LvObstetrics and Gynecology Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Wenjuan WuGuangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510095, China.
Gaoting HuangGuangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510095, China.
Xiaowen YaoGuangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510095, China.
Shirong ZengSun Yat-sen University, Guangzhou, Guangdong, 510080, China.
Yifeng WangObstetrics and Gynecology Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlatinum-based drugs like cisplatin are key in treating ovarian cancer, but resistance frequently leads to treatment failure. The TGF-β1/β- catenin signaling pathway has been implicated in tumor resistance. This study investigates whether hyperthermiaenhances ovarian cancer cell sensitivity to platinum-based drugs by activating the TGF-β1/β-catenin pathway.

methodsRESULTS AND DISCUSSION: Hyperthermia significantly reduced TGF-β1 and β-catenin expression in ovarian cancer cells and tumor tissues, suppressing the pathway. This led to increased cisplatin sensitivity and higher apoptosis rates

conclusionHyperthermia boosts the effectiveness of platinum-based drugs in ovarian cancer by suppressing the TGF-β1/β-catenin pathway, presenting a potential strategy to overcome chemoresistance and improve patient outcomes.

Indexed as

Antineoplastic Agentsbeta CateninCisplatinDrug Resistance, NeoplasmHyperthermia, InducedOvarian NeoplasmsSignal TransductionTransforming Growth Factor beta1AnimalsApoptosisCell Line, TumorFemaleHumansMiceXenograft Model Antitumor AssaysAntineoplastic Agentsbeta CateninCisplatinCTNNB1 protein, humanTGFB1 protein, humanTransforming Growth Factor beta1chemoresistance reversalHyperthermiaOvarian cancerplatinum-based drug sensitivityTGF-β1/β-catenin pathwaythermal medicine

Identifiers

PMID40197181

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.