Evidence map›Paper›PMID 40197239›Full record

ArticleJournal of nanobiotechnology2025

An injectable multifunctional nanocomposite hydrogel promotes vascularized bone regeneration by regulating macrophages.

Huaiyuan Zhang, Yu Wang, Wenyu Qiao, Xueneng Hu, Huifen Qiang, Kuo Xia, Longhai Du, Luling Yang, Yi Bao, Jie Gao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Huaiyuan Zhang *Department of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Yu Wang *Department of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Wenyu Qiao *Department of General Surgery, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Xueneng Hu *Department of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Huifen QiangChanghai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Kuo XiaDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Longhai DuDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Luling YangDigestive Endoscopy Center, School of Medicine, Shanghai Tongren Hospital, Shanghai Jiao Tong University, Shanghai, 200336, China.
Yi BaoBiological Safety Protection 3-Level Laboratory, Guangxi Medical University, Nanning, Guangxi Zhuang, 530021, China.
Jie GaoChanghai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China. gaojiehighclea@smmu.edu.cn.
Tinglin ZhangChanghai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China. ztl2107@smmu.edu.cn.
Zuochong YuDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China. tjyd327@163.com.

Funding

National Key Laboratory 2024 Basic Medicine Innovation Open project JCKFKT-MS-006National Natural Science Foundation of China 82072051National Natural Science Foundation of China 82473263
6 · The paper itself

Abstract

The local inflammatory microenvironment, insufficient vascularization, and inadequate bone repair materials are the three key factors that constrain the repair of bone defects. Here, we synthesized a composite nanoparticle, TPQ (TCP-PDA-QK), with a core‒shell structure. The core consists of nanotricalcium phosphate (TCP), and the shell is derived from polydopamine (PDA). The surface of the shell is modified with a vascular endothelial growth factor (VEGF) mimic peptide (QK peptide). TPQ was then embedded in porous methacrylate gelatin (GelMA) to form a TPQGel hydrogel. In the inflammatory environment, the TPQGel hydrogel can gradually release drugs through pH responsiveness, promoting M2 macrophage polarization, vascularization and bone regeneration in turn. In addition, reprogrammed M2 macrophages stimulate the generation of anti-inflammatory and pro-healing growth factors, which provide additional support for angiogenesis and bone regeneration. The TPQGel hydrogel can not only accurately fill irregular bone defects but also has excellent biocompatibility, making it highly suitable for the minimally invasive treatment of bone defects. Transcriptomic tests revealed that the TPQGel hydrogel achieved macrophage reprogramming by regulating the PI3K-AKT signalling pathway. Overall, the TPQGel hydrogel can be harnessed for safe and efficient therapeutics that accelerate the repair of bone defects.

Indexed as

Bone RegenerationHydrogelsMacrophagesNanocompositesAnimalsBiocompatible MaterialsGelatinIndolesMiceNeovascularization, PhysiologicPolymersRAW 264.7 CellsVascular Endothelial Growth Factor ABiocompatible MaterialsGelatinHydrogelsIndolespolydopaminePolymersVascular Endothelial Growth Factor ABone defectsBone regenerationCore‒shell structureInflammatory microenvironmentM2 macrophage polarizationVascularization

Identifiers

PMID40197239
PMCPMC11978117

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.