Evidence map›Paper›PMID 40197321›Full record

ReviewJournal of neuroinflammation2025

MOG

Erin N Capper, Edward F Linton, Jeffrey J Anders, Randy H Kardon, Oliver W Gramlich

Abstract readReviewComparative Study
In one paragraph

Review in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Upadacitinib Restrains the Pathogenic Fitness of CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Generation of xenobiotic free retinofugal assembloids.Frontiers in cell and developmental biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erin N CapperDepartment of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Edward F LintonDepartment of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Jeffrey J AndersDepartment of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Randy H KardonDepartment of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Oliver W GramlichDepartment of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA. oliver-gramlich@uiowa.edu.

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
Targeting Cholesterol Homeostasis to maintain vision in MS-like optic neuritisR01EY034194 · NEI · UNIVERSITY OF IOWA · PI Oliver W Gramlich · 2023 to 2026
$1.2M
NCATS NIH HHS UL1 TR002537NEI NIH HHS R01 EY034194NIH HHS R01EYE034194 and CTSA UL1TR002537RRD VA I01 RX002978RRD VA I50 RX003002RRD VA IK1 RX005029United States (U.S.) Department of Veterans Affairs Rehabilitation Research and Development Service 1I01RX002978-01 and 1I50RX003002-01
6 · The paper itself

Abstract

Optic neuritis (ON), or inflammation of the optic nerve, is a common presenting symptom of demyelinating neuroinflammatory conditions that result in significant, subacute vision loss. Given its association with visual impairment and varying extent of visual recovery, ON has been recognized as a significant health burden with a need for new therapeutic strategies to improve long-term visual outcomes. Among the resources utilized to study ON, animal models have emerged as powerful tools to examine the underlying pathophysiology and the effectiveness of proposed therapies. In the current review, we discuss the functional and structural phenotypes related to ON in currently used mouse models, and summarize how the pathophysiology and visual phenotype of the myelin oligodendrocyte glycoprotein 35-55 (MOG

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaPeptide FragmentsAnimalsDisease Models, AnimalHumansMiceMyelin Oligodendrocyte Glycoprotein Antibody-Associated DiseaseOptic NerveOptic NeuritisMyelin-Oligodendrocyte Glycoproteinmyelin oligodendrocyte glycoprotein (35-55)Peptide FragmentsAnimal modelsEAEMOGADMSMultiple sclerosisMyelin oligodendrocyte glycoprotein antibody-associated diseaseNeuromyelitis Optica spectrum disorderNMOSDOptic neuritis

Identifiers

PMID40197321
PMCPMC11977933

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.