ReviewCurrent atherosclerosis reports2025
Role of Aspirin in Reducing Risk for Atherosclerotic Cardiovascular Disease in Individuals with Elevated Lipoprotein(a).
Review in Current atherosclerosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Progress in risk assessment and management: Forecasting updates across international cholesterol guidelines.American journal of preventive cardiology · 2026Review
- Why, how and in whom should we measure levels of lipoprotein(a): A review of the latest evidence and clinical implications.Diabetes, obesity & metabolism · 2025Review
- Lp(a): Global Public Health Concern: Emerging Knowledge and Therapeutic Approaches.Current cardiology reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewElevated Lp(a) is associated with increased risk for atherosclerotic cardiovascular disease (ASCVD), and there is currently a lack of targeted therapies for treating individuals with elevated Lp(a). The purpose of this review is to evaluate the current evidence for aspirin therapy for the primary prevention of ASCVD in individuals with elevated Lp(a). RECENT
findingsPrior studies demonstrated an association between aspirin use and a reduction in cardiovascular events among carriers of particular high-risk LPA single nucleotide polymorphisms. More recent studies have extended these findings by incorporating the more clinically available Lp(a) levels, observing an approximately 50% reduction in risk for coronary heart disease events and ASCVD mortality with aspirin use among individuals with Lp(a) > 50 mg/dL. There is growing evidence for a benefit with aspirin therapy in individuals with elevated Lp(a) without clinical ASCVD. The limitations of the available data must be acknowledged, and shared decision making should be used when discussing with patients, particularly when balancing potential bleeding risk. Future studies are needed to provide more definitive guidance regarding primary prevention aspirin therapy in this population.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.