ArticleCancer discovery2025
Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes.
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Article in Cancer discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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What it found
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Who cites it
3 citing papers in PubMed.
- Genetic, cellular, and environmental factors influencing tumourigenesis in carriers of succinate dehydrogenase germline mutations.Endocrine-related cancer · 2026Review
- Epigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations.Communications biology · 2026Article
- FDA fast-track approval of belzutifan is a milestone in rare cancer therapy.Nature reviews. Endocrinology · 2025Article
Corrections and comments
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Authors and funding
61 authors.
Carlota ArenillasBiomarkers and Clonal Dynamics Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0001-7921-9117
Lucía CeladaHealth Research Institute of Asturias (ISPA), University of Oviedo, Oviedo, Spain.ORCID 0000-0002-3058-7231
José Ruiz-CantadorAdult Congenital Heart Disease Unit, Department of Cardiology, Hospital Universitario La Paz, Madrid, Spain.ORCID 0000-0002-0422-6491
Bruna CalsinaHereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0002-6922-9415
Debayan DattaBiomarkers and Clonal Dynamics Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0002-2347-0860
Eduardo García-GaleaOncology Data Science (ODysSey) Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0003-4699-0786
Roberta FasaniMolecular Oncology Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0003-1630-9988
Ana Belén Moreno-CárdenasBiomarkers and Clonal Dynamics Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0001-7743-3873
Juan José Alba-LinaresHealth Research Institute of Asturias (ISPA), University of Oviedo, Oviedo, Spain.ORCID 0000-0001-7189-7685
Berta Miranda-BarrioDepartment of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.ORCID 0000-0003-1617-1050
Ángel M Martínez-MontesHereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0003-1461-4516
Cristina Alvarez-EscolaDepartment of Endocrinology and Nutrition, Hospital Universitario La Paz, Madrid, Spain.ORCID 0000-0003-4448-7941
Beatriz LecumberriDepartment of Endocrinology and Nutrition, Hospital Universitario La Paz, Madrid, Spain.ORCID 0000-0002-3115-9001
Ana González GarcíaAdult Congenital Heart Disease Unit, Department of Cardiology, Hospital Universitario La Paz, Madrid, Spain.ORCID 0000-0002-8596-767X
Shahida K FloresDivision of Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, University of Texas Health Science Center, San Antonio, Texas.ORCID 0009-0006-1476-1945
Emmanuel EsquivelDivision of Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, University of Texas Health Science Center, San Antonio, Texas.ORCID 0000-0003-1219-2508
Yanli DingDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas.ORCID 0000-0001-9554-0461
Mirko PeitzschInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-2472-675X
José-Ángel Robles-GuiradoVall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0002-7654-7446
Rita Maria Regojo ZapataDepartment of Pathology, Hospital Universitario La Paz, Madrid, Spain.ORCID 0000-0003-4486-4647
José Juan Pozo-KreilingerDepartment of Pathology, Hospital Universitario La Paz, Madrid, Spain.ORCID 0000-0001-5895-4112
Carmela IglesiasDepartment of Pathology, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.ORCID 0000-0002-4113-676X
Trisha DwightCancer Genetics, Kolling Institute, Royal North Shore Hospital, Sydney, Australia.ORCID 0000-0003-1943-4514
Christopher A MuirDepartment of Endocrinology, St. Vincent's Hospital, Sydney, Australia.ORCID 0000-0002-1430-0499
Amelia OleagaDepartment of Endocrinology and Nutrition, Hospital Universitario de Basurto, Bilbao, Spain.ORCID 0000-0002-8244-1840
Maria Elvira Garrido-Lestache Rodríguez-MonteDepartment of Pediatric Cardiology, Hospital Universitario Ramón y Cajal, Madrid, Spain.ORCID 0000-0002-2535-5073
Maria Jesús Del CerroDepartment of Pediatric Cardiology, Hospital Universitario Ramón y Cajal, Madrid, Spain.ORCID 0000-0001-8616-8768
Isaac Martínez-BendayánDepartment of Pediatric Cardiology, Instituto de Investigación Biomédica (Cardiopatía Estructural y Congénita) and Complexo Hospitalario Universitario A Coruña, A Coruña, Spain.ORCID 0000-0003-3967-8022
Enol Álvarez-GonzálezHealth Research Institute of Asturias (ISPA), University of Oviedo, Oviedo, Spain.ORCID 0000-0002-6701-9836
Tamara CubiellaHealth Research Institute of Asturias (ISPA), University of Oviedo, Oviedo, Spain.ORCID 0009-0007-0484-5990
Delmar Muniz LourençoEndocrinology Division, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID 0000-0003-1147-4159
Maria Adelaide A PereiraEndocrinology Division, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID 0009-0002-4957-0963
Nelly BurnichonAP-HP, Hôpital Européen Georges Pompidou, Département de Médecine Génomique des Tumeurs et des Cancers, Paris, France.ORCID 0000-0001-7972-5845
Alexandre BuffetAP-HP, Hôpital Européen Georges Pompidou, Département de Médecine Génomique des Tumeurs et des Cancers, Paris, France.ORCID 0000-0002-4742-2708
Craig BrobergAdult Congenital Heart Program, Division of Cardiology, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0002-9797-9803
Paxton V DicksonDepartment of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0002-2345-983X
Mario F FragaHealth Research Institute of Asturias (ISPA), University of Oviedo, Oviedo, Spain.ORCID 0000-0001-8450-2603
José Luis Llorente PendásCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.ORCID 0000-0001-7713-5526
Joaquín Rueda SorianoCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.ORCID 0000-0002-6187-9317
Francisco Buendía FuentesCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.ORCID 0000-0003-0616-2986
Sergio P A ToledoSchool of Medicine, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-2590-3519
Roderick Clifton-BlighDepartment of Endocrinology and Cancer Genetics Unit, Kolling Institute, Royal North Shore Hospital, Sydney, Australia.ORCID 0000-0002-1545-0368
Rodrigo DienstmannOncology Data Science (ODysSey) Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0001-5997-318X
Josep VillanuevaVall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0003-1396-9470
Jaume CapdevilaNeuroendocrine and Endocrine Tumor Translational Research Program (NET-VHIO), Vall Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0003-0718-8619
Anne-Paule Gimenez-RoqueploAP-HP, Hôpital Européen Georges Pompidou, Département de Médecine Génomique des Tumeurs et des Cancers, Paris, France.ORCID 0000-0002-4816-670X
Judith FavierInserm, Centre de recherche des Cordeliers, Université Paris-Cité, Sorbonne Université, Equipe Labellisée Ligue Contre le Cancer, Paris, France.ORCID 0000-0001-8190-5853
Paolo NuciforoMolecular Oncology Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0003-1380-0990
William F YoungDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5481-4884
Nicole BechmannInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-6932-333X
Alexander R OpotowskyCincinnati Adult Congenital Heart Disease Program, Heart Institute, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, Ohio.ORCID 0000-0002-6107-2281
Anand VaidyaDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-0314-9252
Irina BancosDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-9332-2524
Donate WeghornUniversitat Pompeu Fabra (UPF), Barcelona, Spain.ORCID 0000-0001-7722-8618
Mercedes RobledoHereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0001-6256-5902
Anna CasteràsDepartment of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.ORCID 0000-0003-4719-065X
Laura Dos-SubiràIntegrated Adult Congenital Heart Disease Unit, Department of Cardiology, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0001-5821-4501
Igor AdameykoDepartment of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5471-0356
María-Dolores ChiaraHealth Research Institute of Asturias (ISPA), University of Oviedo, Oviedo, Spain.ORCID 0000-0002-1112-1583
Patricia L M DahiaDivision of Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, University of Texas Health Science Center, San Antonio, Texas.ORCID 0000-0002-7757-370X
Rodrigo A ToledoBiomarkers and Clonal Dynamics Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0003-3070-6795
Funding
Evaluating the impact of genetic ancestry on the biology and drug response profile of pheochromocytoma and paraganglioma-derived organoid modelsR01CA264248 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAHIA, PATRICIA LEAL, SORAGNI, ALICE · 2021 to 2025
$3.2MInteraction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complexR01GM114102 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAHIA, PATRICIA LEAL · 2017 to 2021
$1.5MCentres de Recerca de Catalunya (CERCA)Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)European Cooperation in Science and Technology (COST) COST Action CA20122 HarmonisationEuropean Union (ERDF/ESF)-A way to build Europe and Fundació Enric Masip.Fundación BBVA (FBBVA) CAIMI-IFundación Cellex (Cellex Foundation) For providing Institutional research facilities and equipmentFundación Fero (Fundació Fero) Startup grant for VHIO's Biomarkers and Clonal Dynamics LaboratoryInstituto de Salud Carlos III (ISCIII) Miguel Servet #CP17/00199Instituto de Salud Carlos III (ISCIII) #PI20/00895Instituto de Salud Carlos III (ISCIII) #PI20/01754Ministerio de Ciencia, Innovación y Universidades (MCIU) #PID2023-151388OB-I00National Institute of Health #GM114102NCI NIH HHS R01 CA264248Neuroendocrine Tumor Research Foundation (NETRF) #CA264248NIGMS NIH HHS R01 GM114102Paradifference Foundation (The Paradifference foundation)Pheipas Patients Association #91430State Agency for Research Financial support for the Center of Excellence Severo Ochoa (CEX2020-001024-S/AEI/10.13039/501100011
Abstract
significanceThis study reveals a broad convergence in genetic adaptation to hypoxia between natural populations and tumors, suggesting that insights from natural populations could enhance our understanding of cancer biology and identify novel therapeutic targets. See related commentary by Lee, p. 875.
Indexed as
Adaptation, PhysiologicalAltitudeHypoxiaNeoplasmsHumans
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What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.