Evidence map›Paper›PMID 40199585›Full record

ArticleLife science alliance2025

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance.

Jingxian Chen, Rojin Chitrakar, L Ryan Baugh

Abstract read
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. An atlas of thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. microPublication biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jingxian ChenDepartment of Biology, Duke University, Durham, NC, USA.ORCID 0000-0002-1642-6060
Rojin ChitrakarDepartment of Biology, Duke University, Durham, NC, USA.
L Ryan BaughDepartment of Biology, Duke University, Durham, NC, USA ryan.baugh@duke.edu.ORCID 0000-0003-2148-5492

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Systemic, maternal and transgenerational effects of nutrient stressR01GM117408 · NIGMS · DUKE UNIVERSITY · PI BAUGH, LARRY RYAN · 2015 to 2022
$2.5M
Genetic and Genomic Analysis of Starvation Resistance in C. elegansR01GM143159 · NIGMS · DUKE UNIVERSITY · PI BAUGH, LARRY RYAN · 2021 to 2024
$1.2M
NIGMS NIH HHS R01 GM117408NIGMS NIH HHS R01 GM143159NIH HHS P40 OD010440
6 · The paper itself

Abstract

Starvation resistance is a fundamental trait with profound influence on fitness and disease risk. DAF-18, the

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsPTEN PhosphohydrolaseStarvationAnimalsSignal TransductionCaenorhabditis elegans ProteinsDAF-18 protein, C elegansPTEN Phosphohydrolase

Identifiers

PMID40199585
PMCPMC11979363

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.