Evidence map›Paper›PMID 40199816›Full record

ArticleDiscover mental health2025

Mindfulness enhancements predict aberrant salience reductions and improve stress management.

Isabel Wießner, Júlia Paula Souza, Marcelo Demarzo, Luís Fernando Tófoli

Abstract read
In one paragraph

Article in Discover mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Isabel Wießner *Interdisciplinary Cooperation for Ayahuasca Research and Outreach (ICARO), School of Medical Sciences, University of Campinas, Rua Vital Brasil, 80, Cidade Universitária Zeferino Vaz, Campinas, SP, 13083-888, Brazil. isabel.wiessner@gmail.com.ORCID http://orcid.org/0000-0003-1653-2565
Júlia Paula Souza *Department of Preventive Medicine, Centro Mente Aberta, Federal University of São Paulo, Av. Padre José Maria, 545, Santo Amaro, São Paulo, SP, 04753-060, Brazil.ORCID http://orcid.org/0000-0002-1061-3447
Marcelo DemarzoDepartment of Preventive Medicine, Centro Mente Aberta, Federal University of São Paulo, Av. Padre José Maria, 545, Santo Amaro, São Paulo, SP, 04753-060, Brazil.ORCID http://orcid.org/0000-0002-7447-1839
Luís Fernando TófoliInterdisciplinary Cooperation for Ayahuasca Research and Outreach (ICARO), School of Medical Sciences, University of Campinas, Rua Vital Brasil, 80, Cidade Universitária Zeferino Vaz, Campinas, SP, 13083-888, Brazil.ORCID http://orcid.org/0000-0003-2262-8272

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico Research Productivity Grant (1D)
6 · The paper itself

Abstract

backgroundMindfulness improves mental health and clinical conditions including psychosis and modulates attentional processes including salience-the automatic direction of attention to prominent elements. Aberrant salience-the exaggerated significance attribution to perceived elements-is associated with psychotic experiences, but its interactions with mindfulness remain unexplored.

methodsThis pre-post-intervention pilot study included 21 participants completing an 8-week Mindfulness-Based Health Promotion (MBHP) course with measurements before (T0), after (T1), and three months post-course (T2). Primary outcomes were mindful attention (Mindful Attention Awareness Scale, MAAS), decentering (Experiences Questionnaire, EQ), aberrant salience (Aberrant Salience Inventory, ASI), and correlations between time-dependent changes (T1-T0, T2-T0, T2-T1). Secondary outcomes included qualitative reports on Motivations, Learnings, Preferred Practices, and Stress Management.

resultsRegarding mindfulness, MAAS and EQ continuingly increased (T0 vs. T1/T2). Regarding aberrant salience, the factor Heightened Cognition (ASI) increased post-course (T0 vs. T1), whereas Heightened Emotionality (T0 vs. T2) and Total Aberrant Salience (T1 vs. T2) decreased. Importantly, MAAS (T1-T0, T2-T0) correlated negatively with Heightened Emotionality (T2-T0). Qualitative findings revealed consistent stressors but improved stress management, integrated mindfulness practices into participants' daily lives, and potential mechanisms of presence, observation, perspective change, and emotion regulation underlying decreased aberrant salience.

conclusionMindfulness may modulate pre-attentional and attentional processes and improve well-being and stress management, as reflected by reduced aberrant salience and promoted mindful attention and decentering. Our findings suggest that mindful attention may play a crucial role in reducing aberrant salience, offering a promising direction for future research on mindfulness interventions in psychosis.

Indexed as

Aberrant salienceAttentionAwarenessMindfulnessPsychosisStress management

Identifiers

PMID40199816
PMCPMC11979052

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.