ArticleScientific reports2025
The synergistic activity of fisetin on quercetin improves testicular recover in ischemia-reperfusion injury in rats.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Nicotinic and Folic Acid Supplementation Improves Cryopreserved Ram Sperm Quality, Potentially Through Modulation ofInternational journal of molecular sciences · 2026Article
- Thiram inhibits human sperm motility and capacitation by increasing mitochondrial OTranslational andrology and urology · 2026Article
- Role of Fisetin in the Mammalian Reproductive System.Veterinary sciences · 2026Review
- Time-dependent protective effects of syringic acid following testicular torsion-detorsion: an experimental rat model.Acta cirurgica brasileira · 2026Article
- Canthaxanthin enhances the quality of cryopreserved goat spermatozoa.Veterinary research forum : an international quarterly journal · 2026Article
- Moringa oleifera Lam. As a Herbal Antioxidant-Enriched Semen Extender in Cryopreservation: A Critical Review of Its Protective Potential.Veterinary medicine and science · 2026Review
- Can monomethyl fumarate and nifedipine reduce ischemia reperfusion injury in rat ovary, and what is the share of oxidative stress-sensitive transcription factors HIF-1α, NF-κB, and Nrf2?Iranian journal of basic medical sciences · 2026Article
- Efficacy of zinc oxide nanoparticles in chemical castration of male Wistar rats.Scientific reports · 2025Article
- Variations in conventional and non-conventional semen characteristics of selected rabbit breeds.Animal biotechnology · 2025Article
- Oral niacin mitigates heat-induced reproductive impairments in male mice.Scientific reports · 2025Article
- β-Glucan and resveratrol mitigate lead induced reproductive toxicity in male mice.Scientific reports · 2025Article
- The effects of heavy smoking on oxidative stress, inflammatory biomarkers, vascular dysfunction, and hematological indices.Scientific reports · 2025Article
- Allicin and hesperidin protect sperm production from environmental toxins in mice.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examines a potential treatment for testicular ischemia-reperfusion (I/R) injury using fisetin (FIS) and quercetin (QUE) in a rat model. Male rats were divided into five groups: a control group, a torsion/detorsion (T/D) group, and three experimental groups treated with FIS, QUE, or a combination of FIS + QUE. Sperm parameters, oxidative stress markers, histopathological features, RT-PCR analysis of apoptotic and antiapoptotic gene expression, and fertility index were evaluated. The results demonstrated that FIS + QUE, FIS, and QUE significantly improved sperm motility and concentration, leading to a higher fertility index, than the reduced metrics in the T/D group. Additionally, levels of MDA and NO were significantly lowered, while CAT, SOD, GPx, and TAC levels increased in the FIS + QUE, FIS, and QUE groups. Histopathological, RT-PCR and fertility analyses also revealed evidence of apoptosis and testicular damage in the T/D group, shown by significant increases in P53, Bax, and caspase-3, along with marked decreases in AKT, PI3K, and Bcl-2. Treatment with FIS and QUE, particularly in combination, significantly improved outcomes, indicating a strong synergistic effect that helps repair damage and enhance reproductive function after T/D injury.
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