Evidence map›Paper›PMID 40200063›Full record

ArticleCommunications engineering2025

Colloidal-fibrillar composite gels demonstrate structural reinforcement, secondary fibrillar alignment, and improved vascular healing outcomes.

Nina A Moiseiwitsch, Sanika Pandit, Nicole Zwennes, Kimberly Nellenbach, Ana Sheridan, Jessica LeGrand, Eunice Chee, Sarah Ozawa, Brigid Troan, Wen Yih Aw and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Editors' Choice 2025.Communications engineering · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nina A MoiseiwitschJoint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC, USA.ORCID http://orcid.org/0000-0001-7406-0258
Sanika PanditJoint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC, USA.
Nicole ZwennesJoint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC, USA.
Kimberly NellenbachJoint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC, USA.
Ana SheridanJoint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC, USA.ORCID http://orcid.org/0000-0003-0255-6929
Jessica LeGrandComparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.
Eunice CheeJoint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC, USA.
Sarah OzawaComparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.
Brigid TroanDepartment of Physiology and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Wen Yih AwJoint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC, USA.
William PolacheckJoint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC, USA.ORCID http://orcid.org/0000-0003-2728-0746
Mansoor A HaiderComparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.
Ashley C BrownJoint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC, USA. aecarso2@ncsu.edu.ORCID http://orcid.org/0000-0001-6995-1785

Funding

Fibrin-Based Nanoparticles as a Novel Sealant for Vascular AnastomosisF30HL163869 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOISEIWITSCH, NINA ALEXANDRA · 2022 to 2025
$187k
National Science Foundation (NSF) CMMI 2235857; DGE-2137100NHLBI NIH HHS F30 HL163869U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL146701; 5F30HL163869U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 5T34GM131947-05; 5T32GM133366
6 · The paper itself

Abstract

Many biological tissues contain colloids within a fibrillar structure. Here, we develop and characterize colloidal-fibrillar scaffolds through examination of the effects of relative colloid and fiber ratios within a fibrin-based model system composed of fibrin-based nanoparticles (FBNs) within a natural fibrin scaffold. At lower concentrations, FBNs primarily integrate into the fibrillar fibrin matrix, strengthening it. At high concentrations, colloid-colloid interactions dominate and FBNs primarily form a highly aligned secondary structure that does not strengthen the fibrillar matrix. At intermediate concentrations, both reinforcement of the fibrin matrix and colloid-colloid interactions are observed. Our characterization of this colloidal-fibrillar system provides insight into new avenues for wound healing biomaterial development. Using structural and mechanical results, we developed a biomimetic surgical sealant. When applied to a vascular healing model, FBN gel resulted in improved vessel healing. This colloidal-fibrillar composite can greatly improve healing outcomes and should be applied to other tissues.

Identifiers

PMID40200063
PMCPMC11978784

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.