RBM24 regulates apoptosis rates by modulating global transcriptome profile in CAL27 cells.

Jingjing Sun, Shuyuan Wang, Shumin Peng, Tingting Gao, Zhenjie Gao

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jingjing Sun *Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

Shuyuan Wang *Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

Shumin PengDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

Tingting GaoDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

Zhenjie GaoDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. kqgzj@zzu.edu.cn.

Funding

Henan Provincial Medical Science and Technology Tackling Project LHGJ20220362National Natural Science Foundation of China 81901039

6 · The paper itself

Abstract

RNA binding proteins (RBPs) are key factors regulating post-transcriptional events. Categorized as RBPs, RBM24 expression levels have been shown to be a prognosis-related pivotal gene in oral squamous cell carcinoma. We analyzed the binding targets and regulated post-transcriptional events of RBM24 in RBM24-overexpressing cell lines and controls using iRIP-seq and RNA-seq. RBM24-overexpressing cells showed significant changes in gene expression, which are involved in biological pathways related to apoptosis and immune inflammation. RBM24-regulated genes that undergo alternative splicing are primarily engaged in biological processes related to DNA damage repair and RNA metabolism. More notably, we found that RBM24 binds to lncRNAs in addition to pre-mRNAs. These results indicated that RBM24 could play a key role in cancer progression by finding clinical therapeutic targets for Oral squamous cell carcinoma.

Indexed as

ApoptosisCarcinoma, Squamous CellMouth NeoplasmsRNA-Binding ProteinsTranscriptomeAlternative SplicingCell Line, TumorGene Expression ProfilingGene Expression Regulation, NeoplasticHumansRNA, Long NoncodingRNA-Binding ProteinsRNA, Long NoncodingAlternative splicingApoptosisCancer therapyOral squamous cell carcinomaRBM24

Identifiers

PMID40200085

DOI10.1038/s41598-025-96932-5

PMCPMC11978760

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.