Evidence map›Paper›PMID 40200131›Full record

ArticleBMC plant biology2025

Uncovering the key miRNA-target network of tea plants in resistance to sooty mold disease.

Shuangshuang Wang, Ran Zhang, Litao Sun, Xiuxiu Xu, Jiazhi Shen, Xiaojiang Li, Chaoling Wei, Zhaotang Ding, Shengrui Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Exploring the CeRNA landscape in plants: advances, methods, and challenges.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuangshuang WangTea Research Institute, Shandong Academy of Agricultural Sciences, Jinan, China.
Ran ZhangSericultural Research Institute, Anhui Academy of Agricultural Sciences, Hefei, China.
Litao SunTea Research Institute, Shandong Academy of Agricultural Sciences, Jinan, China.
Xiuxiu XuTea Research Institute, Shandong Academy of Agricultural Sciences, Jinan, China.
Jiazhi ShenTea Research Institute, Shandong Academy of Agricultural Sciences, Jinan, China.
Xiaojiang LiTea Research Institute, Shandong Academy of Agricultural Sciences, Jinan, China.
Chaoling WeiState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
Zhaotang DingTea Research Institute, Shandong Academy of Agricultural Sciences, Jinan, China. dzttea@163.com.
Shengrui LiuState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China. liushengrui@ahau.edu.cn.

Funding

Natural Science Foundation of Shandong Province ZR2021QC092Open Fund of State Key Laboratory of Tea Plant Biology and Utilization SKLTOF20220104
6 · The paper itself

Abstract

backgroundSooty mold (SM) disease severely threatens tea plant health, reducing yield and quality. Driven by climate change and intensive farming practices, SM prevalence in China has surged, causing significant economic losses and forcing farmers to rely on chemical fungicides, which compromise environmental sustainability. Despite its impact, the molecular mechanisms underlying tea plant defenses against SM remain unclear.

resultsIntegrated transcriptomic, sRNAome, and degradome analyses revealed that differentially expressed genes (DEGs) exhibited infection-level-dependent expression patterns. Post-transcriptional regulation by miRNAs was identified through sRNAome-degradome mapping, with six miRNA-target defense pairs validated by 5' RLM-RACE and qRT-PCR. Co-expression network analysis showed that two miRNA-target pairs, PC-5p-33681_128-auxin response factor (CsARF) and ppe-MIR535b-p3-1ss12TC-aldehyde dehydrogenase (CsALDH), play crucial roles in responding to SM infection. Furthermore, 5' RLM-RACE and dual-luciferase assays revealed that the PC-5p-33681_128 and ppe-MIR535b-p3-1ss12TC could regulate the expression of CsARF and CsALDH by mRNA cleavage, respectively.

conclusionThis study elucidates miRNA-mediated defense networks in tea plants against SM, offering actionable targets for breeding SM-resistant cultivars via genetic engineering or marker-assisted selection. Implementing these strategies could reduce yield losses, stabilize farmer incomes, and minimize environmental harm from fungicide overuse. This work advances climate-resilient practices for the global tea industry by linking molecular insights to sustainable agriculture.

Indexed as

Camellia sinensisDisease ResistanceMicroRNAsPlant DiseasesGene Expression Regulation, PlantGene Regulatory NetworksRNA, PlantMicroRNAsRNA, PlantDefense responseIntegration analysismiRNA-target circuitsSooty mold diseaseTea plants

Identifiers

PMID40200131
PMCPMC11980228

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.