SynthesisInternational journal of occupational medicine and environmental health2025
Environmental exposure to selected non-persistent endocrine disrupting chemicals and polycystic ovary syndrome: a systematic review.
Synthesis in International journal of occupational medicine and environmental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Review
- The Role of Antioxidants in the Management of Polycystic Ovary Syndrome.Antioxidants (Basel, Switzerland) · 2026Review
- Integrative bioinformatics, single-cell and experimental evidence for a BPA-m6A-apoptosis axis in granulosa cell dysfunction in polycystic ovary syndrome.Journal of ovarian research · 2026Article
- Melatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis.Animals : an open access journal from MDPI · 2025Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycystic ovary syndrome (PCOS) is an endocrine disorder manifesting with symptoms such as irregular menstrual cycles, hyperandrogenism, and/or polycystic ovaries. The exact cause of PCOS remains unknown, but it is believed to result from a combination of genetic predisposition, insulin resistance, low-grade inflammation, and excessive androgen production. Various environmental factors, especially endocrine-disrupting chemicals (EDCs), in addition to genetic and hormonal ones, also may influence PCOS. This is one of the first systematic reviews dealing with the exposure to non-persistent endocrine disrupting chemicals and PCOS. The review summarizes the existing knowledge about the association of EDCs with PCOS based on significant findings on the toxicity of various non-persistent environmental EDCs and polycyclic ovarian syndrome risk. A systematic search of the literature was conducted in order to identify proper studies using PubMed, Scopus, Elsevier, and Springer databases. The results of the studies suggest that there is a positive association between bisphenol A (BPA), phthalates, octocrylene, and PCOS. The data concerning triclosan and PCOS were inconclusive. Additionally, no link between the exposures to parabens and PCOS was observed. These results of the presented studies highlight the urgent need for continued research on EDCs and their role in PCOS. Int J Occup Med Environ Health. 2025;38(2):98-121.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.