Evidence map›Paper›PMID 40200785›Full record

ArticleInternational journal of fertility & sterility2025

Investigation of The Placental Levels of Vascular Endothelial Growth Factor B and Selenoprotein P and Their Relation with Birth Weight in Patients with Pre-eclampsia: A Case-Control Study.

Hadi Eslahi, Mohsen Saravani, Mansour Shahraki, Abolfazl Payandeh, Mahnaz Rezaei, Marzieh Ghasemi, Saeedeh Salimi, Mahjob Sargazi-Taghazi

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Article in International journal of fertility & sterility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hadi EslahiChildren and Adolescents Health Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran.
Mohsen SaravaniDepartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Email: moh.saravani@zaums.ac.ir.
Mansour ShahrakiChildren and Adolescents Health Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran.
Abolfazl PayandehInfectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
Mahnaz RezaeiDepartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Marzieh GhasemiDepartment of Obstetrics and Gynecology, Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Saeedeh SalimiDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahjob Sargazi-TaghaziDepartment of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPre-eclampsia is a serious medical condition characterised by high blood pressure and signs of organ damage that is associated with adverse pregnancy outcomes, including low birth weight. Selenoprotein P (SELENOP) and vascular endothelial growth factor B (VEGF-B) are antioxidants that can improve the condition of this disease. This study aims to investigate the placental levels of SELENOP and VEGF-B, and their association with birth weight in pregnant women with pre-eclampsia compared to healthy pregnant women. MATERIALS AND

methodsThis case-control study enrolled 30 pregnant women with pre-eclampsia as the case group and 30 healthy pregnant women as the control group. Demographic information and anthropometric indices were collected and recorded in forms. Placental levels of SELENOP and VEGF-B were assessed by a commercial human kit and based on enzyme-linked immunosorbent assay (ELISA). P<0.05 indicated statistical significance.

resultsThe mean placental level of VEGF-B in pregnant women with pre-eclampsia was lower than the healthy group (P=0.001) as was the mean placental level of SELENOP compared to the healthy group (P=0.048). No significant correlation existed between placental levels of SELENOP (r=0.253, P=0.051) and VEGF-B (r=0.671, P=0.056) with birth weight.

conclusionOur findings showed that pregnant women with pre-eclampsia had lower levels of VEGF-B and SELENOP compared to healthy pregnant women. The findings may assist with pre-eclampsia diagnosis, management, and prediction, and benefit mothers and babies.

Indexed as

Pre-eclampsiaPregnancySelenoprotein PVascular Endothelial Growth Factor B

Identifiers

PMID40200785
PMCPMC11976889

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.