Evidence map›Paper›PMID 40201123›Full record

ArticleiScience2025

Insulin acts on astrocytes to shift their substrate preference to fatty acids.

Bouchra Taib, Pragney Deme, Sujasha Gupta, Seung Wan Yoo, Saja S Khuder, Ahmet Hoke, Zhigang Li, Rexford S Ahima, Norman J Haughey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bouchra TaibThe Johns Hopkins University School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Baltimore, MD, USA.
Pragney DemeThe Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
Sujasha GuptaThe Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
Seung Wan YooThe Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
Saja S KhuderThe Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
Ahmet HokeThe Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
Zhigang LiThe Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
Rexford S AhimaThe Johns Hopkins University School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Baltimore, MD, USA.
Norman J HaugheyThe Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.

Funding

NLRP inflammasome directed activation of the innate immune system produces synaptic damage in EcoHIV infected mice self-administering fentanylR01DA052272 · NIDA · JOHNS HOPKINS UNIVERSITY · PI HAUGHEY, NORMAN J · 2020 to 2024
$2.8M
NIDA NIH HHS R01 DA052272
6 · The paper itself

Abstract

It is increasingly recognized that brain can β-oxidize fatty acids for use as an energy substrate. However, mechanism(s) by which neural cells switch their preference from glucose to fatty acids are not fully elucidated. Here we provide evidence that insulin acts directly on astrocytes to promote the uptake of glucose and fatty acids while modifying their substrate preference through a sequential shift in the expression of genes associated with fatty acid uptake, synthesis, transport, and metabolism. Under these conditions, fatty acids are converted into TCA cycle intermediates to satisfy astrocyte energy demands, allowing pyruvate derived from glucose to be directed toward the production of lactate; a preferred fuel for neurons. This shift in astrocyte energy substrate preference is required for insulin to enhance long-term potentiation in the Schaffer collateral. These findings establish a homeostatic mechanism where insulin promotes LTP by switching the energy substrate preference of astrocytes to fatty acids.

Indexed as

Biological sciencesCellular neuroscienceNatural sciencesNeuroscienceSystems neuroscience

Identifiers

PMID40201123
PMCPMC11978350

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.