ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Association of Conventional and Unconventional Lipid Profiles with Visceral Fat Area in Overweight/Obese Individuals with Type 2 Diabetes Mellitus.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- An explainable machine learning method for identifying key atherogenic lipid biomarkers in abdominal obesity among the Southern Chinese population.Lipids in health and disease · 2026Article
- Adherence to the Mediterranean diet and its association with atherogenic indices and lipid profile in individuals seeking a weight-loss dietary program: what role for body fat?Lipids in health and disease · 2026Article
- The Relationship Between Visceral Fat Obesity and the Atherogenic Combined Index in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Visceral fat area and blood lipids in colorectal cancer: predictors of surgical risk and prognosis.Frontiers in oncology · 2026Article
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8 authors.
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Abstract
Background: Several lipid metabolism-related profiles have been explored for their association with obesity, but no consensus has been reached. Therefore, this study aimed to comprehensively analyze the correlation between conventional and unconventional lipid profiles and visceral fat area (VFA) in overweight/obese patients with type 2 diabetes mellitus (T2DM). Emphasizing the overall relationship between lipid metabolism and visceral fat accumulation. Methods: This cross-sectional study included 1288 overweight/obese T2DM patients, with VFA measured using bioelectrical impedance analysis and visceral fat obesity (VFO) was defined as VFA ≥ 100 cm². Both conventional lipid profiles include total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and lipoprotein(a), and unconventional lipid profiles include lipid composite index (LCI), platelet/ HDL-c ratio (PHR), remnant cholesterol (RC), TG/HDL-c, Castelli Risk Index I (CRI-I), Castelli Risk Index II (CRI-II), Non-HDL-c, atherogenic index of plasma (AIP) and atherogenic coefficient (AC) were analyzed. The study population was divided into non-VFO and VFO groups, The relationship between conventional and unconventional lipid profiles and VFO was evaluated. Results: Compared to the non-VFO group, the VFO group exhibited significantly higher levels of TG, lipoprotein(a), LCI, RC, TG/HDL-c, CRI-I, CRI-II, AIP, and AC (all P < 0.05). Univariate analysis revealed that RC, TG, LCI, TG/HDL-c, CRI-I, CRI-II, AIP, and AC were positively correlated with VFA and VFO, while HDL-c and lipoprotein(a) were negatively correlated (all P < 0.05). Logistic regression identified RC as an independent risk factor for VFO (OR: 1.667, 95% CI: 1.216-2.285, P = 0.001). Conclusion: Among lipid profiles, RC is independently and significantly associated with VFO, underscoring its role in lipid metabolism and abdominal obesity management, especially in overweight/obese T2DM patients.
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