Evidence map›Paper›PMID 40201841›Full record

ArticleOpen veterinary journal2025

In

Ratih Rinendyaputri, Sela Septima Mariya, Dany Frans, Ariyani Noviantari, Dwi Budiono, Lisa Andriani Lienggonegoro, Hasta Handayani Idrus, Wireni Ayuningtyas, Rachmawati Noverina, Fathul Huda and 1 more

Abstract read
In one paragraph

Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ratih RinendyaputriCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia.
Sela Septima MariyaCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia.
Dany FransCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia.
Ariyani NoviantariCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia.
Dwi BudionoVeterinary Paramedic Study Program, Collage of Vocational Studies, IPB University, Bogor, Indonesia.
Lisa Andriani LienggonegoroCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia.
Hasta Handayani IdrusCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia.
Wireni AyuningtyasBio Farma Stem Cell Research and Development, Bandung, Indonesia.
Rachmawati NoverinaBio Farma Stem Cell Research and Development, Bandung, Indonesia.
Fathul HudaDepartment of Neurology, Faculty of Medicine, Dr Hasan Sadikin Central General Hospital/Universitas Padjadjaran, Bandung, Indonesia.
Ahmad FariedNeurosurgery Department, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Primary cells have the same heterogeneity and differentiation capacity that has potential as an Aim: This research will prove the demonstration of neurons as an ischemic stroke model and the effects of B27 in Methods: Neurons were obtained from a collection of biological materials collected during previous research. Neuronal validation was performed using immunocytochemistry with the marker β-tubulin. Expression of the apoptotic response was performed by real time- polymerase chain reaction/(RT-PCR) using Bax, BCL-2, caspase-9, and p53 gene markers. Characterization of neurons in terms of positive tβubulin markers and induction of OGD in neurons can be performed for 6 h to model ischemic stroke. Results: This study showed that cultured neurons under OGD conditions can experience apoptosis, namely by increasing pro-apoptosis and decreasing anti-apoptosis. However, B27 supplementation increased the expression of anti-apoptotic Bcl-2 genes and decreased proapoptotic genes such as Bax, caspase 9, and p53. Conclusion: Neuron culture from Mf can be used as an

Indexed as

Ischemic StrokeMacaca fascicularisNeuronsAnimalsApoptosisCells, CulturedDisease Models, AnimalGlucoseGlucoseIschemic strokeMacaca fascicularisNeuronOGDOxygen glucose deprivation

Identifiers

PMID40201841
PMCPMC11974307

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.