ReviewNaunyn-Schmiedeberg's archives of pharmacology2025
Comprehensive review of leonurine: harnessing its therapeutic potential for chronic diseases.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Leonurine Ameliorates Doxorubicin-Induced Cardiotoxicity via STING/NF-κB/NLRP3 Inflammasome Signaling Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pharmacokinetics, Excretion, and Metabolite Profiling of Leonurine in Rats: Evidence for Extensive Phase II Conjugations.Molecules (Basel, Switzerland) · 2026Article
- Protective Effects of Leonurine on Alcoholic Liver Injury Through Modulation of Oxidative Stress and JAK2-STAT3 Signaling.Current issues in molecular biology · 2026Article
- Leonurine (SCM-198) exerts protective effects on pancreatic β-cells in type 1 diabetes by modulating the Bax/Bcl-2/Caspase-3 signaling pathway.BMC complementary medicine and therapies · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Chronic diseases (CD) pose a significant global health challenge, affecting millions of individuals and contributing to substantial morbidity, mortality, and healthcare burden. Therapeutic approaches primarily aim at symptom management through pharmacotherapy, lifestyle modifications, dietary interventions, and regular physical activity. Given the persistent challenge of limited treatment options, scientific research has increasingly focused on exploring natural compounds for their therapeutic potential. Leonurine, a natural compound first isolated from the plant Herba leonuri in 1930, has garnered significant attention due to its extensive pharmacological properties relevant to the treatment of CDs. Extensive studies over the past have revealed that leonurine exhibits anticancer, antidiabetic, anti-inflammatory, and antioxidant activities. These effects are mediated through the modulation of various signaling pathways, including the TGF-β/Smad2, Nrf-2, JNK, NF-κB, BDNF/TrkB/CREB, TLR4/NF-κB/TNF-α, ATF4/CHOP/ASCL4, Akt, HIF-1, SHH/GLI, and mTOR/ERK, whose dysregulation is implicated in the pathogenesis of various CDs. Furthermore, leonurine regulates the levels of multiple pro-inflammatory cytokines, including numerous interleukins and TNF-α, indicating its potential in treating a wide range of chronic conditions, including cardiovascular, neurological, skeletal, and renal diseases. This review seeks to present an in-depth analysis of leonurine's therapeutic potential, emphasizing its promise in the management of various CDs. It also outlines potential avenues for future research to fully harness its pharmacological advantages in treating these conditions.
Indexed as
Identifiers
40202674What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.