Evidence map›Paper›PMID 40204124›Full record

ArticleDiabetes research and clinical practice2025

Connecting underlying factors in the associations between perceived neighborhood social environments and type 2 Diabetes: Serial mediation analyses.

Kosuke Tamura, Mohammad Moniruzzaman, Breanna J Rogers, Yangyang Deng, Lu Hu, Ram Jagannathan

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PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes research and clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Kosuke TamuraSocio-Spatial Determinants of Health (SSDH) Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA. Electronic address: kosuke.tamura@nih.gov.
Mohammad MoniruzzamanSocio-Spatial Determinants of Health (SSDH) Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.
Breanna J RogersSocio-Spatial Determinants of Health (SSDH) Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.
Yangyang DengSocio-Spatial Determinants of Health (SSDH) Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.
Lu HuDepartment of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Ram JagannathanEmory Global Diabetes Research Center, Woodruff Health Sciences Center, Emory University, Atlanta, GA, USA; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Funding

Socio-Spatial Determinants of Health (SSDH) ZIAMD000020 · NIMHD · NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES · PI TAMURA, KOSUKE · 2021 to 2025
$1.0M
Intramural NIH HHS ZIA MD000020
6 · The paper itself

Abstract

aimsThis study tested direct and indirect associations between perceived neighborhood social environments and type 2 diabetes (T2D), serially mediated via health-related (physical activity [PA], body mass index [BMI]), psychosocial factors, and inflammation.

methodsData came from the Midlife in the United States (MIDUS 3 [2013-2014] and MIDUS 3 Biomarker Project [2017-2022]; n = 518). T2D (yes/no) was based on the American Diabetes Association criteria. Perceived neighborhood social cohesion and safety were assessed separately (higher scores = more favorable neighborhoods). PA, BMI, perceived stress, depression, and c-reactive protein (CRP) were included as mediators in the associations between exposure and the outcome adjusting for covariates.

resultsHigher social cohesion was indirectly related to lower likelihood of T2D, serially mediated through PA, BMI, and CRP (odds ratio [OR] = 1.00; 95 % bias-corrected confidence interval [BC CI] = 0.99, 1.00). Higher social cohesion and safety were indirectly associated with a lower likelihood of T2D, serially mediated via stress, depression, and CRP (Social cohesion: OR = 0.98; 95 % BC CI = 0.96, 1.00; and safety: OR = 0.98; 95 % BC CI = 0.96, 1.00, all p < 0.05).

conclusionsThis study may be the first to demonstrate underlying potential mechanisms through which socially cohesive and safe neighborhoods lower the risk of T2D. These pathways present potential targets for interventions to reduce the risk.

Indexed as

Diabetes Mellitus, Type 2Neighborhood CharacteristicsSocial Determinants of HealthAgedBiomarkersBody Mass IndexC-Reactive ProteinDepressionExerciseFemaleHealth SurveysHumansInflammationLongitudinal StudiesMaleMediation AnalysisBiomarkersC-Reactive ProteinDiabetesHealth behaviorsInflammatory biomarkersPerceived neighborhood social contextsPsychological stressors

Identifiers

PMID40204124
PMCPMC12094889

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.