Evidence map›Paper›PMID 40204378›Full record

Observational studyJournal of the American College of Cardiology2025

Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women.

Vineetha Mathew, Raiyan R Khan, Amanda R Jowell, Qi Yan, Itsik Pe'er, Buu Truong, Pradeep Natarajan, Lynn M Yee, Sadiya S Khan, Garima Sharma and 11 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American College of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Hypertensive disorders of pregnancy and women's health throughout the life course: an update review 2025-2026.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Vineetha MathewTufts University School of Medicine, Boston, Massachusetts, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA.
Raiyan R KhanDepartment of Computer Science, Columbia University, New York, New York, USA.
Amanda R JowellDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Qi YanDepartment of Computer Science, Columbia University, New York, New York, USA.
Itsik Pe'erDepartment of Computer Science, Columbia University, New York, New York, USA.
Buu TruongProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA.
Pradeep NatarajanProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
Lynn M YeeDepartment of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sadiya S KhanDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Garima SharmaInova Heart and Vascular Institute, Falls Church, Virginia, USA.
Aniruddh P PatelProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
So Mi Jemma ChoProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA.
Maria A PabonDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Rebecca B McNeilRTI International, Durham, North Carolina, USA.
Jillyn SpencerIntermountain Health Women and Newborn Research Department, Intermountain Healthcare, Salt Lake City, Utah, USA.
Robert M SilverDepartment of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Lisa D LevinePregnancy and Perinatal Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
William A GrobmanDepartment of Obstetrics and Gynecology, Brown University School of Medicine, Providence, Rhode Island, USA.
Janet M CatovDepartment of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David M HaasDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Michael C HonigbergProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address: mhonigberg@mgh.harvard.edu.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Stress and Racial Disparities in Preeclampsia - Clues from DNA Methylomic ProfilingU01HL145358 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI Philip Greenland, Rebecca Boehm McNeil · 2020 to 2026
$24.6M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063036 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2010 to 2015
$19.5M
Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes Supplement RequestU10HL119991 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2013 to 2018
$12.6M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Prevention of Preterm Birth in high Risk Nulliparous PatientsU10HD063047 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2010 to 2014
$1.9M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063053 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2010 to 2014
$1.7M
Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk U10HD063020 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GROBMAN, WILLIAM ADAM · 2010 to 2014
$1.6M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063046 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WING, DEBORAH A · 2010 to 2014
$1.6M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063041 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SIMHAN, HYAGRIV N · 2010 to 2014
$1.5M
American Heart Association-American Stroke Association 24RGRSG1275749American Heart Association-American Stroke Association 940166NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR001108NHLBI NIH HHS K08 HL166687NHLBI NIH HHS U01 HL145358NHLBI NIH HHS U10 HL119989NHLBI NIH HHS U10 HL119990NHLBI NIH HHS U10 HL119991NHLBI NIH HHS U10 HL119992NHLBI NIH HHS U10 HL119993NHLBI NIH HHS U10 HL120006NHLBI NIH HHS U10 HL120018NHLBI NIH HHS U10 HL120019NHLBI NIH HHS U10 HL120034NICHD NIH HHS U10 HD063020NICHD NIH HHS U10 HD063036NICHD NIH HHS U10 HD063037NICHD NIH HHS U10 HD063041NICHD NIH HHS U10 HD063046NICHD NIH HHS U10 HD063047NICHD NIH HHS U10 HD063048NICHD NIH HHS U10 HD063053NICHD NIH HHS U10 HD063072
6 · The paper itself

Abstract

backgroundHypertensive disorders of pregnancy (HDPs) (preeclampsia/eclampsia and gestational hypertension) are a leading cause of maternal and perinatal morbidity and mortality and are associated with long-term maternal cardiovascular disease. High genetic risk and poor cardiovascular health (CVH) are each associated with HDPs, but whether genetic risk for HDP is modified by CVH status in early pregnancy is unknown.

objectivesIn this study, the authors sought to test the independent and joint associations of genetic risk and first-trimester CVH with development of HDP.

methodsWe examined genotyped participants from the nuMoM2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be), a prospective observational cohort that enrolled nulliparous individuals with singleton pregnancies from 2010 to 2013 at 8 U.S. clinical sites. Genetic risk was calculated according to a validated genetic risk score for HDP. A first-trimester CVH score was closely adapted from the American Heart Association Life's Essential 8 model. Genetic risk and CVH were each categorized as low (bottom quintile), intermediate (quintile 2-4), or high (top quintile). The primary outcome was development of HDP. Multivariable-adjusted logistic regression was used to test the independent and joint associations of genetic risk and CVH with development of HDPs.

resultsAmong 7,499 participants (mean age 27.0 years), the median first-trimester CVH score was 77.1 (Q1-Q3: 67.1-85.7). Overall, 1,032 participants (13.8%) developed an HDP (487 [6.5%] preeclampsia, 545 [7.3%] gestational hypertension). Genetic risk and CVH were each independently and additively associated with HDP (high vs low genetic risk: adjusted OR [aOR]: 2.21 [95% CI: 1.78-2.77; P < 0.001]; low vs high CVH: aOR: 2.92 [95% CI: 2.28-3.74; P < 0.001]). There was no significant interaction between genetic risk and CVH regarding risk of HDPs (P

conclusionsLower genetic risk and higher first-trimester CVH were independently and additively associated with lower risk of developing HDPs in nulliparous individuals. Favorable CVH in early pregnancy may mitigate high genetic risk for HDP.

Indexed as

Genetic Predisposition to DiseaseHypertension, Pregnancy-InducedParityPregnancy Trimester, FirstAdultFemaleHumansPre-EclampsiaPregnancyProspective StudiesRisk AssessmentRisk Factorscardiovascular healthhypertensionhypertensive disorders of pregnancypolygenic risk scorespreventive cardiology

Identifiers

PMID40204378
PMCPMC12042077

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.