SynthesisJournal of orthopaedic surgery and research2025
Efficacy and safety of platelet-rich plasma combined with core decompression and enhanced bone grafting versus core decompression with enhanced bone grafting alone in treating femoral head necrosis: a systematic review and meta-analysis.
Synthesis in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Chinese clinical practice guidelines for minimally invasive hip preservation techniques for femoral head osteonecrosis (2025 edition).International orthopaedics · 2026Review
- Analysis of the efficacy of autologous adipose-derived stromal vascular fraction and calcium phosphate bone cement combined with core decompression in patients with femoral head necrosis: a retrospective study.BMC musculoskeletal disorders · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe efficacy and safety of platelet-rich plasma (PRP) combined with core decompression (CD)-enhanced bone grafting for the treatment of osteonecrosis of the femoral head remains controversial. This study aimed to conduct a systematic review and meta-analysis of the efficacy and safety of PRP combined with CD-enhanced bone grafting for treating osteonecrosis of the femoral head and to compare this method with CD-combined bone grafting as a way to provide theoretical bases for future clinical treatments and research.
objectiveThis study aimed to assess the improved efficacy and safety of core decompression combined with platelet-rich plasma-enhanced bone grafting for osteonecrosis of the femoral head compared to core decompression-enhanced bone grafting.
methodWe systematically searched several databases for randomised controlled trials comparing bone graft and core decompression with or without PRP, including 16 studies involving 999 subjects and 1139 hip cases. This meta-analysis followed the Preferred Reporting Items (PRISMA) guidelines. The study is registered with PROSPERO under code CRD42024557968.
result16 articles involving 999 patients (1139 hips) were included in this study. Pooled analyses demonstrated that when core decompression-enhanced bone grafting was combined with PRP, the Harris hip score (mean difference [MD]: 5.26, 95% Cl:4.81-5.71; P < 0.00001), visual analog scale (MD: -0.74, 95% Cl:-0.99 - -0.49; P < 0.00001) and reduction in the need for THA: (risk ratio [RR]: 0.29; 95% Cl:0.16-0.53; P < 0.0001) were superior to core decompression-enhanced bone grafting alone. Furthermore, a pooled analysis confirmed the safety of PRP [RR:0.33; 95% Cl:0.13-0.83; P = 0.02]. All these results were statistically significant.
conclusionCompared to CD-enhanced bone grafting, the combination of PRP appears to yield superior therapeutic outcomes in restoring hip function, alleviating pain, preventing THA, and ensuring postoperative safety. Moreover, we require a higher level of randomised controlled trials to evaluate its efficacy and safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.