Evidence map›Paper›PMID 40205503›Full record

ArticleActa neuropathologica communications2025

Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus.

Lihan Liu, Yue Wang, Xiaolin Wang, Guowen Zhang, Sha Sha, Rong Zhou, Yimei Du, Chunfeng Wu, Lei Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lihan LiuDepartment of Physiology, Nanjing Medical University, No. 101, Longmian Ave, Nanjing, Jiangsu Province, 211166, P.R. China.
Yue WangDepartment of Physiology, Nanjing Medical University, No. 101, Longmian Ave, Nanjing, Jiangsu Province, 211166, P.R. China.
Xiaolin WangDepartment of Physiology, Nanjing Medical University, No. 101, Longmian Ave, Nanjing, Jiangsu Province, 211166, P.R. China.
Guowen ZhangDepartment of Physiology, Nanjing Medical University, No. 101, Longmian Ave, Nanjing, Jiangsu Province, 211166, P.R. China.
Sha ShaDepartment of Physiology, Nanjing Medical University, No. 101, Longmian Ave, Nanjing, Jiangsu Province, 211166, P.R. China.
Rong ZhouDepartment of Physiology, Nanjing Medical University, No. 101, Longmian Ave, Nanjing, Jiangsu Province, 211166, P.R. China.
Yimei DuResearch Center of Ion Channelopathy, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430022, P.R. China.
Chunfeng WuDepartment of Neurology, Children's Hospital of Nanjing Medical University, No.8, Jiangdong South Road, Nanjing, Jiangsu Province, 211166, P. R. China. wcf1108@njmu.edu.cn.ORCID 0009-0007-9967-8987
Lei ChenDepartment of Physiology, Nanjing Medical University, No. 101, Longmian Ave, Nanjing, Jiangsu Province, 211166, P.R. China. chenl@njmu.edu.cn.ORCID 0000-0002-7382-8306

Funding

National Natural Science Foundation of China 81971274National Natural Science Foundation of China 82170326
6 · The paper itself

Abstract

Pyroptosis contributes to the neuronal damage that occurs during epilepsy. Calcium-activated neutral protease (calpain) dissociates cysteinyl aspartate specific proteinase-1 (caspase-1, cas-1) from the cytoskeleton, and the activated cas-1 is responsible for the production of N-terminus of gasdermin D (N-GSDMD), the final executor of pyroptosis. Blocking transient receptor potential vanilloid 4 (TRPV4) can reduce neuronal injury in temporal lobe epilepsy (TLE) model mice. This study investigated the role of TRPV4 in pyroptosis during TLE. In the hippocampus of pilocarpine-induced status epilepticus (PISE) mice, the ratio of inactive calpain 1 protein level to its total protein level (inactive/total calpain 1) significantly decreased, while the ratio of inactive calpain 2 protein level to its total protein level remained unchanged. The protein levels of NLRP3, cleaved cas-1 (c-cas-1), interleukin (IL)-1β, and N-GSDMD increased, with more GSDMD-immunofluorescence-positive (GSDMD

Indexed as

HippocampusPyroptosisStatus EpilepticusTRPV Cation ChannelsAnimalsCalpainCaspase 1Disease Models, AnimalGasderminsMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinPhosphate-Binding ProteinsPilocarpineSulfonamidesCalpainCapn1 protein, mouseCaspase 1GasderminsGsdmd protein, mouseNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePhosphate-Binding ProteinsPilocarpineSulfonamidesTrpv4 protein, mouseTRPV Cation ChannelsCalpainCaspase-1Gasdermin DPyroptosisTemporal lobe epilepsyTransient receptor potential vanilloid 4

Identifiers

PMID40205503
PMCPMC11983898

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.