Evidence map›Paper›PMID 40205689›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2025

Resistance and Impact Training During Weight Loss Improves Physical Function and Body Composition in Older Adults With Obesity.

Jakub Mesinovic, Anoohya Gandham, Mavil May Cervo, Paul Jansons, Costas Glavas, Michael Braude, Juan Pena Rodriguez, Barbora De Courten, Ayse Zengin, Belinda R Beck and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jakub MesinovicInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.ORCID https://orcid.org/0000-0003-1297-2731
Anoohya GandhamDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Mavil May CervoDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Paul JansonsInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.
Costas GlavasInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.
Michael BraudeDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Juan Pena RodriguezDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Barbora De CourtenDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Ayse ZenginDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Belinda R BeckMenzies Health Institute Queensland, Griffith University, Gold Coast campus, Southport, Queensland, Australia.
Peter R EbelingDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
David ScottInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.

Funding

National Health and Medical Research Council Investigator GNT1174886National Health and Medical Research Council Investigator GNT1197958Rebecca L. Cooper Medical Research Foundation
6 · The paper itself

Abstract

backgroundWeight loss achieved via energy restriction leads to significant losses in muscle and bone mass, potentially increasing risk for sarcopenia and osteoporosis. High-intensity resistance and impact training (HiRIT) might attenuate weight loss-induced musculoskeletal declines. Our objective was to compare changes in physical function and body composition in older adults with obesity undertaking dietary weight loss combined with HiRIT or aerobic training (AT).

methodsSixty older adults (aged ≥ 60 years) with obesity (dual-energy x-ray absorptiometry determined body fat percentage ≥ 30% in men and ≥ 40% in women) and a mobility limitation (Short Physical Performance Battery [SPPB] score ≤ 11) were randomly assigned to either 12 weeks of supervised, centre-based HiRIT or self-directed, home-based AT while consuming a hypocaloric diet (750-1000 kcal/day reduction in energy intake). Changes in physical function (primary outcome: gait speed) and body composition were compared between groups.

resultsA total of 49/60 randomised participants (mean age: 69.6 ± 6 years; 58% women; mean BMI: 32.9 ± 4.1 kg/m

conclusionHiRIT appears to be safe and more effective than AT for improving gait speed in older adults with obesity undertaking dietary weight loss. Additional trials with larger sample sizes and longer durations are warranted to explore whether HiRIT can attenuate weight loss-related muscle and bone mass declines.

trial registrationAustralian New Zealand Clinical Trials: ACTRN12618001146280.

Indexed as

Body CompositionObesityResistance TrainingWeight LossAgedFemaleHumansMaleMiddle AgedPhysical Functional Performanceaerobic trainingboneexercisemuscleobesityolder adultsresistance and impact trainingsarcopeniaweight loss

Identifiers

PMID40205689
PMCPMC11981955

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.