Evidence map›Paper›PMID 40205739›Full record

ArticleBiophysical journal2025

SNARE complex assembly and disassembly dynamics in response to Ca

Qinghua Fang, Ying Zhao, Dong An, Manfred Lindau

Abstract read
In one paragraph

Article in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Membrane fusion and budding.Biophysical journal · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Qinghua FangLaboratory for Nanoscale Cell Biology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
Ying ZhaoLaboratory for Nanoscale Cell Biology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
Dong AnDepartment of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida.
Manfred LindauLaboratory for Nanoscale Cell Biology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany; Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida. Electronic address: mxl2044@miami.edu.

Funding

Molecular mechanisms of exocytotic vesicle fusion and release.R35GM139608 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LINDAU, MANFRED · 2021 to 2025
$1.9M
Mechanisms of Vesicle Fusion and Transmitter ReleaseR01GM121787 · NIGMS · CORNELL UNIVERSITY · PI LINDAU, MANFRED · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM121787NIGMS NIH HHS R35 GM139608
6 · The paper itself

Abstract

A SNAP25-based FRET construct named SCORE (SNARE complex reporter) has revealed a transient FRET increase that specifically occurred at fusion sites preceding fusion events by tens of milliseconds and presumably reflects vesicle priming. The FRET increase lasts for a few seconds until it is reversed. In those experiments, the FRET increase was found to be localized to areas <0.5 μm

Indexed as

CalciumSNARE ProteinsAnimalsChromaffin CellsFluorescence Resonance Energy TransferMiceSynaptosomal-Associated Protein 25CalciumSNARE ProteinsSynaptosomal-Associated Protein 25

Identifiers

PMID40205739
PMCPMC12256900

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.