Evidence map›Paper›PMID 40206055›Full record

Article3 Biotech2025

Protective effects of ascorbic acid against anticancer drug-induced oxidative stress and genotoxic damage in

Ana Maria Oliveira Ferreira da Mata, Reyca Rodrigues E Silva, Antônio Lima Braga, Ricardo Melo de Carvalho, José Victor de Oliveira Santos, Marcus Vinícius Oliveira Barros de Alencar, Márcia Correia Fernanda Jardim Paz, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ana Maria Oliveira Ferreira da MataNortheast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí-UFPI, Teresina, Piauí 64049-550 Brazil.
Reyca Rodrigues E SilvaLaboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64049-550 Brazil.
Antônio Lima BragaLaboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64049-550 Brazil.
Ricardo Melo de CarvalhoNortheast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí-UFPI, Teresina, Piauí 64049-550 Brazil.
José Victor de Oliveira SantosLaboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64049-550 Brazil.
Marcus Vinícius Oliveira Barros de AlencarNortheast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí-UFPI, Teresina, Piauí 64049-550 Brazil.
Márcia Correia Fernanda Jardim PazNortheast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí-UFPI, Teresina, Piauí 64049-550 Brazil.
Siddique Akber AnsariDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451 Riyadh, Saudi Arabia.
Irfan Aamer AnsariDepartment of Drug Science and Technology, University of Turin, 10124 Turin, Italy.
Muhammad Torequl IslamPharmacy Discipline, Khulna University, Khulna, 9208 Bangladesh.ORCID 0000-0001-6392-3820
João Marcelo de Castro E SousaNortheast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí-UFPI, Teresina, Piauí 64049-550 Brazil.
Felipe Cavalcanti Carneiro da SilvaNortheast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí-UFPI, Teresina, Piauí 64049-550 Brazil.
Ana Amélia de Carvalho Melo CavalcanteNortheast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí-UFPI, Teresina, Piauí 64049-550 Brazil.
Benedito Borges da SilvaNortheast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí-UFPI, Teresina, Piauí 64049-550 Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The widely used dietary antioxidant ascorbic acid (AA) is evident to possess protective effects against many chronic diseases. This study aimed to evaluate the effects of AA on oxidative stress and genotoxic damage caused by 5-fluorouracil (5-FU), docetaxel (DOCE), and tamoxifen (TAMOX) in two proficient and four isogenic

Indexed as

Anticancer drugsAscorbic acidCombination therapyGenotoxicityOxidative stressProtective effects

Identifiers

PMID40206055
PMCPMC11977090

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.