Evidence map›Paper›PMID 40207157›Full record

ArticleFrontiers in microbiology2025

Li Chen, Dan Luo, Hua Xiao, Zhuo Zeng, Haodang Luo, Siqi Gao, Xiaoqian Tang, Zhijia Huang, Yanhua Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li Chen *Basic Medical School, Hengyang Medical College, Institute of Pathogenic Biology, University of South China, Hengyang, Hunan, China.
Dan Luo *Department of Clinical Laboratory, The Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Hua XiaoBasic Medical School, Hengyang Medical College, Institute of Pathogenic Biology, University of South China, Hengyang, Hunan, China.
Zhuo ZengBasic Medical School, Hengyang Medical College, Institute of Pathogenic Biology, University of South China, Hengyang, Hunan, China.
Haodang LuoBasic Medical School, Hengyang Medical College, Institute of Pathogenic Biology, University of South China, Hengyang, Hunan, China.
Siqi GaoBasic Medical School, Hengyang Medical College, Institute of Pathogenic Biology, University of South China, Hengyang, Hunan, China.
Xiaoqian TangBasic Medical School, Hengyang Medical College, Institute of Pathogenic Biology, University of South China, Hengyang, Hunan, China.
Zhijia HuangDepartment of Critical Care Medicine, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Yanhua ZengBasic Medical School, Hengyang Medical College, Institute of Pathogenic Biology, University of South China, Hengyang, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: In this work, after SV-HUC-1 cells were stimulated with rMgPa, autophagy was detected using Western blotting, immunofluorescence and transmission electron microscopy, respectively. Western blotting and Annexin V/PI assays were used to determine the signaling pathway involved in rMgPa- inhibited apoptosis via inducing autophagy. Results: rMgPa upregulated the autophagy-related proteins ATG7 and LC3B while downregulating P62 expression in SV-HUC-1 cells. Transmission electron microscopy showed the presence of intracellular autophagosomes, and indirect immunofluorescence confirmed the enhanced expression of LC3B, indicating that rMgPa induces autophagy. Silencing of CypA significantly attenuated rMgPa-induced autophagy, highlighting the essential role of CypA in this process. Furthermore, rMgPa was found to regulate the PI3K/AKT/mTOR pathway via CypA, thereby promoting autophagy. Western blot analysis and Annexin V/PI assays confirmed that rMgPa-induced autophagy inhibits apoptosis in urothelial cells through a CypA-dependent mechanism. Conclusion: This study demonstrates that rMgPa suppresses apoptosis in SV-HUC-1 cells by inducing autophagy via CypA-mediated modulation of the PI3K/AKT/mTOR pathway, which elucidates a novel survival strategy employed by

Indexed as

apoptosisautophagycyclophilin AMGPAMycoplasma genitalium

Identifiers

PMID40207157
PMCPMC11979137

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.