Evidence map›Paper›PMID 40207364›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2025

Endothelial Stiffening Induced by CD36-Mediated Lipid Uptake Leads to Endothelial Barrier Disruption and Contributes to Atherosclerotic Lesions.

Victor Aguilar, Elizabeth Le Master, Amit Paul, Sang Joon Ahn, Dana Lazarko, Maria Febbraio, Dolly Mehta, James C Lee, Irena Levitan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victor Aguilar *Departments of Medicine (V.A., E.L.M., A.P., S.J.A., D.L., I.L.), University of Illinois at Chicago.
Elizabeth Le Master *Departments of Medicine (V.A., E.L.M., A.P., S.J.A., D.L., I.L.), University of Illinois at Chicago.
Amit Paul *Departments of Medicine (V.A., E.L.M., A.P., S.J.A., D.L., I.L.), University of Illinois at Chicago.
Sang Joon AhnDepartments of Medicine (V.A., E.L.M., A.P., S.J.A., D.L., I.L.), University of Illinois at Chicago.
Dana LazarkoDepartments of Medicine (V.A., E.L.M., A.P., S.J.A., D.L., I.L.), University of Illinois at Chicago.
Maria FebbraioFaculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada (M.F.).ORCID 0000-0001-7142-8440
Dolly MehtaPharmacology (D.M.), University of Illinois at Chicago.ORCID 0000-0003-0945-9304
James C LeeBiomedical Engineering (V.A., J.C.L., I.L.), University of Illinois at Chicago.ORCID 0000-0002-7173-4875
Irena LevitanDepartments of Medicine (V.A., E.L.M., A.P., S.J.A., D.L., I.L.), University of Illinois at Chicago.ORCID 0000-0003-3072-6497

Funding

The Lung Endothelium as an Instructive Niche for the Innate Immune System during Vascular InjuryP01HL160469 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jalees Rehman · 2022 to 2026
$14.0M
Cholesterol Regulation of Endothelial K+ ChannelsR01HL073965 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LEVITAN, IRENA · 2004 to 2024
$7.3M
Impact of dyslipidemia on endothelial biomechanicsR01HL083298 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEVITAN, IRENA, MINSHALL, RICHARD D · 2007 to 2021
$7.0M
Roles of Tau Oligomers in Alzheimer's VasculopathyR01AG044404 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI LEE, JAMES C · 2014 to 2024
$3.5M
Microvascular endothelial Kir channels in flow-induced dilation and hypertensionR01HL141120 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEVITAN, IRENA, PHILLIPS, SHANE A · 2019 to 2022
$2.5M
Vascular Biology, Signaling and Therapeutics training programT32HL144459 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KITAJEWSKI, JAN K., WARY, KISHORE K · 2019 to 2023
$1.6M
Endothelial biomechanics in vascular agingR56AG082099 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEVITAN, IRENA, MINSHALL, RICHARD D · 2023 to 2023
$328k
NHLBI NIH HHS P01 HL160469NHLBI NIH HHS R01 HL073965NHLBI NIH HHS R01 HL083298NHLBI NIH HHS R01 HL141120NHLBI NIH HHS T32 HL144459NIA NIH HHS R01 AG044404NIA NIH HHS R56 AG082099
6 · The paper itself

Abstract

backgroundEndothelial stiffening induced by Western diet was proposed to be an important factor in vascular dysfunction. In this study, we determine the role of endothelial CD36 (cluster of differentiation 36) in stiffening, disruption of aortic endothelial barrier, and atherosclerosis in mouse models of obesity and hypercholesterolemia.

methodsTo address this goal, we generated an endothelial-specific inducible knockdown mouse model of CD36, Cdh5.CreER

resultsEndothelial-specific downregulation of CD36 abrogates stiffening of aortic endothelium induced by Western diet in Cdh5.CreER

conclusionsWe conclude that stiffening of the aortic endothelium by CD36-mediated uptake of fatty acids contributes significantly to Western diet-induced vascular dysfunction and atherosclerosis. We further propose that fatty acids may activate RhoA by inducing its dissociation from Rho-GDI1.

Indexed as

AortaAortic DiseasesAtherosclerosisCapillary PermeabilityCD36 AntigensEndothelial CellsEndothelium, VascularPlaque, AtheroscleroticVascular StiffnessAnimalsAntigens, CDCadherin 5CadherinsCells, CulturedDiet, WesternDisease Models, AnimalAntigens, CDCadherin 5CadherinsCD36 AntigensCD36 protein, humanCd36 protein, mouseReceptors, LDLrhoA GTP-Binding ProteinRhoA protein, mouseaortaatherosclerosisdyslipidemiaendotheliumvascular function

Identifiers

PMID40207364
PMCPMC12312798

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.