Evidence map›Paper›PMID 40207685›Full record

ArticleClinical and translational science2025

Exploratory Study of Sex Differences in P-Glycoprotein Function at the Blood-Brain Barrier.

Giordana Salvi de Souza, Wanling Liu, Pascalle Mossel, Joost F Somsen, Anna L Bartels, Cristiane R G Furini, Adriaan A Lammertsma, Charalampos Tsoumpas, Gert Luurtsema

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. FromACS omega · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giordana Salvi de SouzaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0003-2243-3141
Wanling LiuDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0001-7159-5759
Pascalle MosselDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-1526-6923
Joost F SomsenDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0009-0009-0761-9002
Anna L BartelsDepartment of Neurology, Ommelander Ziekenhuis Groningen, Scheemda, the Netherlands.ORCID 0009-0002-9293-1402
Cristiane R G FuriniSchool of Medicine, PUCRS, Porto Alegre, Brazil.ORCID 0000-0003-1609-7727
Adriaan A LammertsmaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0003-1237-2891
Charalampos TsoumpasDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-4971-2477
Gert LuurtsemaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0001-8599-8129

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Permeability-glycoprotein (P-gp), a crucial efflux pump transporter encoded by the ABCB1 gene, plays a pivotal role in drug disposition at the blood-brain barrier (BBB) and is involved in the pharmacokinetics of numerous therapeutic agents. This study investigates differences in P-gp function at the BBB between males and females in a cohort of older (55+) healthy volunteers (HV) using [

Indexed as

ATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Blood-Brain BarrierAgedCyclosporinsFemaleHealthy VolunteersHumansMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsSex CharacteristicsSex FactorsABCB1 protein, humanATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1CyclosporinsRadiopharmaceuticalsvalspodarABCB1 geneless‐invasive quantificationlong axial field of view PETpharmacokineticsquantitative analysis

Identifiers

PMID40207685
PMCPMC11983324

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.