Evidence map›Paper›PMID 40208346›Full record

ArticleJournal of cancer research and clinical oncology2025

Low-intensity pulsed ultrasound affects proliferation and migration of human hepatocellular carcinoma cells.

Mingzhen Yang, Zhihui Lu, Bangzhong Liu, Guanghua Liu, Mingfang Shi, Ping Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mingzhen Yang *Department of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhihui Lu *Department of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Bangzhong LiuDepartment of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Guanghua LiuDepartment of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Mingfang ShiDepartment of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. shi.mingfang@zs-hospital.sh.cn.
Ping WangDepartment of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. wang.ping8@zs-hospital.sh.cn.

Funding

Shanghai Research Institute of Rehabilitation Medicine Integrating Traditional Chinese and Western Medicine Project 2024XKPT20-RC1
6 · The paper itself

Abstract

purposeLow-intensity pulsed ultrasound (LIPUS) is an effective ancillary treatment modality for various malignancies. However, the mechanisms underlying the role of LIPUS in cancer treatment have not been fully elucidated. We investigated the effects and underlying mechanism of LIPUS on the proliferation, apoptosis, migration, and invasion of hepatocellular carcinoma (HCC) cells.

methodsThe HCC cell lines SMMC7721 and HCCLM3 were exposed to 1 MHz LIPUS at intensities of 0.5, 1.0, 1.5 W/cm

resultsThe results showed that different intensities of ultrasound affected cellular activity, inhibited cell proliferation and cloning, facilitated intracellular cytoskeletal protein reorganization, and induced cell apoptosis, particularly at the intensity of 1.5 W/cm

conclusionsAlthough LIPUS induced cell apoptosis and inhibited cell proliferation, it also promoted the invasion and metastasis of HCC cells under certain conditions, which was related to the regulation of matrix metallopeptidases and epithelial-mesenchymal transition-related proteins.

Indexed as

Carcinoma, HepatocellularCell MovementCell ProliferationLiver NeoplasmsUltrasonic TherapyUltrasonic WavesAnimalsApoptosisCell Line, TumorEpithelial-Mesenchymal TransitionHumansMembrane Potential, MitochondrialMiceMice, Inbred BALB CMice, NudeReactive Oxygen SpeciesReactive Oxygen SpeciesApoptosisEpithelial-mesenchymal transitionHepatocellular carcinomaLow-intensity pulsed ultrasound

Identifiers

PMID40208346
PMCPMC11985662

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.