Evidence map›Paper›PMID 40208436›Full record

ArticleBiogerontology2025

Spermidine toxicity in Saccharomyces cerevisiae due to mitochondrial complex III deficiency.

Wei-Hsuan Su, Jessica J Smith, Evien Cheng, Megan S Nishitani, Catherine Y Choi, Kelsey R Lee, Alexia Pardos Salzano, Samuel E Schriner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei-Hsuan SuSchool of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA.
Jessica J SmithSchool of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA.
Evien ChengSchool of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA.
Megan S NishitaniSchool of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA.
Catherine Y ChoiSchool of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA.
Kelsey R LeeSchool of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA.
Alexia Pardos SalzanoSchool of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA.
Samuel E SchrinerSchool of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA. schriner@uci.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermidine is a naturally occurring polyamine present in all cells and is necessary for viability in eukaryotic cells. The cellular levels of spermidine decline as an organism ages, and its supplementation has been found to extend lifespan in yeast, worms, flies, mice, and human cultured cells. The lifespan extending effect of spermidine is thought to be due to its ability to induce autophagy, a turnover of cellular components. Mitochondrial dysfunction is believed to be a major driver of the aging process. We asked whether spermidine could rescue mitochondrial dysfunction using the yeast Saccharomyces cerevisiae lacking mtDNA (ρ

Indexed as

Electron Transport Complex IIIMitochondriaSaccharomyces cerevisiaeSpermidineAutophagyDNA, MitochondrialOxidative StressSaccharomyces cerevisiae ProteinsDNA, MitochondrialElectron Transport Complex IIISaccharomyces cerevisiae ProteinsSpermidineAgingMitochondrial DNAMitochondrial dysfunctionSpermidineYeast

Identifiers

PMID40208436
PMCPMC11985560

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.