Evidence map›Paper›PMID 40208448›Full record

SynthesisInternational urology and nephrology2025

Prevalence of BK virus and BK virus-associated hemorrhagic cystitis in stem cell transplant recipients: a systematic review and meta-analysis.

Ambanna Yappalparvi, Mahalaqua Nazli Khatib, Muhammed Shabil, Suhas Ballal, Pooja Bansal, Balvir S Tomar, Pranchal Rajput, Ashish Singh Chauhan, MRavi Kumar, Abhay M Gaidhane and 5 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ambanna Yappalparvi *Centre Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University,, Rajpura, India.
Mahalaqua Nazli Khatib *Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India.
Muhammed ShabilUniversity Center for Research and Development, Chandigarh University, Mohali, Punjab, 140413, India.
Suhas BallalDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India.
Pooja BansalDepartment of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India.
Balvir S TomarInstitute of Pediatric Gastroenterology and Hepatology, NIMS University, Jaipur, India.
Pranchal RajputSchool of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University Dehradun, Dehradun, India.
Ashish Singh ChauhanDepartment of Pharmaceutics, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, 248007, India.
MRavi KumarDepartment of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, 531162, India.
Abhay M GaidhaneJawaharlal Nehru Medical College, and Global Health Academy, School of Epidemiology and Public Health, Datta Meghe Institute of Higher Education, Wardha, India.
Priyanka ChoudharyDepartment of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Rampura Phul, Bathinda, Punjab, 151103, India.
Sanjit SahDepartment of Paediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, 411018, India.
Diptismita JenaComputer Science and Engineering, Graphic Era (Deemed to Be University), Clement Town, Dehradun, 248002, India.
Ganesh BushiSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India. ganeshbushi313@gmail.com.
Doddolla LingamaiahCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe BK virus (BKV) commonly affects stem cell transplant (SCT) patients and can lead to hemorrhagic cystitis (HC), a serious condition that negatively impacts patient health. This study reviews the frequency of BKV infections in SCT patients, particularly those who develop HC.

methodsWe searched Web of Science, PubMed, and Embase up to August 10, 2024, to identify relevant articles focusing on the prevalence of BKV-related hemorrhagic cystitis (HC) in stem cell transplant (SCT) patients. Two reviewers independently screened and extracted data using Nested Knowledge software. A meta-analysis of pooled prevalence rates was conducted using random-effects models in R software, version 4.4. Study heterogeneity was assessed with the I

resultsOf the 2700 articles identified, 15 met our inclusion criteria, encompassing 7856 participants. The overall pooled prevalence of BKV-related hemorrhagic cystitis (HC) was 12.8% (95% CI 8.7-18.5%), with rates varying significantly from 5.0 to 45.9%. This variation reflects differences in patient backgrounds, transplant methods, and diagnostic approaches (I

conclusionsOur study identified a substantial prevalence of BKV-associated hemorrhagic cystitis in stem cell transplant patients, highlighting the importance of vigilant monitoring and effective treatment strategies to manage this risk. Enhancing both diagnostic techniques and treatment approaches is crucial for improving patient outcomes.

Indexed as

BK VirusCystitisHemorrhagePolyomavirus InfectionsStem Cell TransplantationTumor Virus InfectionsCystitis, HemorrhagicHumansPrevalenceBK virusHemorrhagic cystitisMeta-analysisStem cell transplantationSystematic review

Identifiers

PMID40208448

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.