ArticleMethods in molecular biology (Clifton, N.J.)2025
Isolation and Culture of Human Dermal Fibroblasts.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dermal fibroblasts are the main cell type present in skin connective tissue (dermis). They are responsible for the synthesis of dermal extracellular matrix (ECM), providing mechanical stability for the dermal layer. In addition, fibroblasts interact with epidermal cells during hair development and in interfollicular skin cells through bidirectional interactions and secretion of growth factors and cytokines. The changes in the fibroblast population correlate with structural, compositional, quantitative, and qualitative transformations of the main ECM proteins in the dermis, as well as with the age-related disorders, and the state and proliferative activity of basal keratinocytes that are the main cells in the epidermis. Moreover, fibroblasts play an essential role during cutaneous wound healing and in bio-engineering of skin. Hence, culture of primary fibroblast is gaining in importance. In addition, fibroblast cultures established from skin biopsies provide a powerful tool for investigating normal skin physiology or specific disease states. In this chapter, detailed procedures for the establishing and maintaining primary cultures of adult human dermal fibroblasts are described.
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Registered trials
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