Evidence map›Paper›PMID 40208640›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

Docosahexaenoic Acid and Its Metabolites Protect against Ozone-induced Pulmonary Inflammation.

Michael J Yaeger, Tyson Ngatikaura, Natali Zecchino, Hannah B Lovins, Evangeline Schott, Samuel J Cochran, Grace Hutton, Jessica L Ray, Brett Saunders, Laura A Leuenberger and 13 more

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Heterogeneous Causes of Acute Respiratory Distress Syndrome Correlate With Distinct Peripheral Polyunsaturated Fatty Acid Metabolites.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Michael J YaegerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0000-0001-7039-6360
Tyson NgatikauraDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0009-0009-6406-383X
Natali ZecchinoDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0009-0007-5455-2555
Hannah B LovinsDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0009-0000-6088-9217
Evangeline SchottDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0009-0004-2013-4249
Samuel J CochranDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0000-0001-7314-4265
Grace HuttonDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0009-0004-1100-1786
Jessica L RayDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0000-0002-5387-9026
Brett SaundersDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0009-0005-4325-4515
Laura A LeuenbergerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0000-0002-8991-6554
Brita Kilburg-BasnyatDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina.ORCID 0000-0002-6133-4800
Rafia VirkDepartment of Nutrition, Gilling's School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-1729-6616
Rachel Van DuinenDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan.ORCID 0000-0003-2249-7233
Xiaokui MoDepartment of Biomedical Informatics and.ORCID 0000-0002-9797-2687
Michael ArmstrongDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado; and.ORCID 0009-0005-4955-7111
Matthew I McFaddenDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio.
Jenifer I FentonDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan.ORCID 0000-0002-8875-3239
Nichole ReisdorphDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado; and.ORCID 0000-0002-0425-8012
Adriana ForeroDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio.ORCID 0000-0002-2698-658X
Megan N BallingerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0000-0002-2202-3049
Robert M TigheDepartment of Medicine, Duke University, Durham, North Carolina.ORCID 0000-0002-3465-9861
Saame Raza ShaikhDepartment of Nutrition, Gilling's School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0003-1950-2521
Kymberly M GowdyDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Institute, College of Medicine, Wexner Medical Center, and.ORCID 0000-0002-7227-0697

Funding

Dietary EPA mitigates ozone induced pulmonary inflammation through ChemR23 signalingR01ES031378 · NIEHS · OHIO STATE UNIVERSITY · PI Kymberly Mae Gowdy, SAAME R SHAIKH · 2020 to 2026
$3.7M
The pivotal role of macrophages in regulating pulmonary fibrosisR01HL141217 · NHLBI · OHIO STATE UNIVERSITY · PI BALLINGER, MEGAN N · 2019 to 2023
$2.5M
Identification of novel type III IFN regulatory pathwaysR35GM150806 · NIGMS · OHIO STATE UNIVERSITY · PI Adriana Forero · 2023 to 2026
$1.6M
Integrative Research Training Program in Pediatric Cardiopulmonary DiseaseT32HL166149 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Carl Backes, Vidu Garg · 2023 to 2026
$1.4M
Training Program in the Biology of Aging and Lung DiseasesT32HL166132 · NHLBI · OHIO STATE UNIVERSITY · PI Rama K Mallampalli, Ana Lucia Mora · 2024 to 2026
$1.1M
NHLBI NIH HHS L30 HL175819NHLBI NIH HHS R01 HL141217NHLBI NIH HHS T32 HL166132NHLBI NIH HHS T32 HL166149NIEHS NIH HHS F31ES036102-02NIEHS NIH HHS R01 ES031378NIGMS NIH HHS R35 GM150806
6 · The paper itself

Abstract

Ozone (O

Indexed as

Docosahexaenoic AcidsOzonePneumoniaAnimal FeedAnimalsCytokinesDietary SupplementsFemaleLungMacrophagesMiceMice, Inbred C57BLNeutrophilsOxylipinsCytokinesDocosahexaenoic AcidsOxylipinsOzonedocosahexaenoic acidinflammationlungozonespecialized proresolving mediator

Identifiers

PMID40208640
PMCPMC12622229

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.