Evidence map›Paper›PMID 40209395›Full record

ArticleEnvironment international2025

Greenspace and depression incidence in the US-based nationwide Nurses' Health Study II: A deep learning analysis of street-view imagery.

Li Yi, Jaime E Hart, Charlotte Roscoe, Unnati V Mehta, Marcia Pescador Jimenez, Pi-I Debby Lin, Esra Suel, Perry Hystad, Steve Hankey, Wenwen Zhang and 3 more

Abstract read
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Urban greenspace and dementia: Measures, mechanisms, and methodological guidance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
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  12. GPS-based street-view greenspace exposure and wearable assessed physical activity in a prospective cohort of US women.The international journal of behavioral nutrition and physical activity · 2025
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Li YiDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: li_yi@hsph.harvard.edu.
Jaime E HartChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: rejch@channing.harvard.edu.
Charlotte RoscoeDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA; Environmental Systems and Human Health, Oregon Health & Science University Portland State University School of Public Health, Portland, OR, USA. Electronic address: roscoe@ohsu.edu.
Unnati V MehtaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: umehta94@gmail.com.
Marcia Pescador JimenezDepartment of Epidemiology, Boston University School of Public of Health, Boston, MA, USA. Electronic address: jimenezm@bu.edu.
Pi-I Debby LinDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA. Electronic address: p_lin@hphci.harvard.edu.
Esra SuelCentre for Advanced Spatial Analysis, University College London, London, UK. Electronic address: e.suel@ucl.ac.uk.
Perry HystadCollege of Health, Oregon State University, Corvallis, OR, USA. Electronic address: perry.hystad@oregonstate.edu.
Steve HankeySchool of Public and International Affairs, Virginia Polytechnic Institute and State University, Blacksburg, USA. Electronic address: hankey@vt.edu.
Wenwen ZhangEdward J. Bloustein School of Planning and Public Policy, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA. Electronic address: wenwen.zhang@ejb.rutgers.edu.
Olivia I OkerekeChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. Electronic address: Olivia.Okereke@mgh.harvard.edu.
Francine LadenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: nhfrl@channing.harvard.edu.
Peter JamesDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Public Health Sciences, University of California Davis School of Medicine, Davis, CA, USA. Electronic address: pjames@ucdavis.edu.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
Built Environment Assessment through Computer visiON (BEACON): Applying Deep Learning to Street-Level and Satellite Images to Estimate Built Environment Effects on Cardiovascular HealthR01HL150119 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JAMES, PETER · 2020 to 2024
$3.9M
Environmental Resources for Individual Cognitive Health/Resilience (EnRICH)R01AG087199 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Marcia Ixchel Pescador Jimenez · 2024 to 2026
$2.3M
Neurodegenerative diseases and the role of green space: A deep learning assessmentR00AG066949 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PESCADOR JIMENEZ, MARCIA IXCHEL · 2022 to 2024
$738k
Neurodegenerative diseases and the role of green space: A deep learning assessmentK99AG066949 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI PESCADOR JIMENEZ, MARCIA IXCHEL · 2020 to 2021
$248k
NCI NIH HHS U01 CA176726NHLBI NIH HHS R01 HL150119NHLBI NIH HHS U01 HL145386NIA NIH HHS K99 AG066949NIA NIH HHS R00 AG066949NIA NIH HHS R01 AG087199NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

backgroundGreenspace exposure is associated with lower depression risk. However, most studies have measured greenspace exposure using satellite-based vegetation indices, leading to potential exposure misclassification and limited policy relevance. We examined the association of street-view greenspace measures with incident depression in a prospective cohort of US women.

methodsWe applied deep learning segmentation models to 350 million US street-view images nationwide (2007-2020) to derive ground-level greenspace metrics, including percentage of trees, grass, and other greenspace (plants/flowers/fields), and linked metrics to Nurses' Health Study II participants' residences (N = 33,490) within 500 m each year. Cox proportional hazards models estimated the relationship between street-view greenspace metrics and incident depression, assessed through self-report of clinician-diagnosed depression or regular antidepressant use and adjusted for individual- and area-level factors.

findingsIn adjusted models, higher percentages of street-view trees were inversely associated with incident depression (HR per IQR, 0.98; 95%CI: 0.94-1.01) and specifically clinician-diagnosed depression (HR per IQR, 0.94; 95%CI: 0.90-0.99). Higher percentages of street-view grass were also inversely associated with incident depression, but only in areas with low particulate matter (PM CONCLUSION AND RELEVANCE: We observed participants who lived in areas with more trees visible in street-view images had a lower risk of depression. Our findings suggest tree-planting interventions may reduce depression risk.

Indexed as

Deep LearningDepressionAdultFemaleHumansIncidenceMiddle AgedNursesProspective StudiesUnited States

Identifiers

PMID40209395
PMCPMC12224280

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.