Evidence map›Paper›PMID 40210376›Full record

ReviewNeuroimaging clinics of North America2025

Imaging Interstitial Fluids and Extracellular Matrix in Cerebrovascular Disorders: Current Perspectives and Clinical Applications.

Grant McGee Talkington, Blake Ouvrier, Amanda Louise White, Gregory Hall, Meenakshi Umar, Gregory Jaye Bix

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroimaging clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Grant McGee TalkingtonDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA. Electronic address: gtalkington@tulane.edu.
Blake OuvrierDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA.
Amanda Louise WhiteDepartment of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Gregory HallDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Meenakshi UmarDepartment of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Gregory Jaye BixDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA; Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Funding

Investigating the role of Alpha5Beta1 integrin in cognitive dysfunctionRF1AG078677 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BIX, GREGORY JAYE, BURANDA, TIONE · 2023 to 2024
$2.4M
CTSA Predoctoral T32 at the University of Alabama at BirminghamT32TR004767 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jennifer S Pollock · 2024 to 2026
$1.7M
NCATS NIH HHS T32 TR004767NIA NIH HHS RF1 AG078677
6 · The paper itself

Abstract

This article provides a comprehensive review of current neuroimaging techniques for visualizing and quantifying extracellular matrix (ECM) components and interstitial fluid (ISF) dynamics in cerebrovascular disorders. It examines how alterations in ECM composition and ISF movement patterns correlate with various cerebrovascular pathologies, including ischemic stroke, frontotemporal dementia, cerebral small vessel disease, Alzhheimer's disease, and vascular dementia. The review emphasizes novel imaging markers specific to ECM/ISF alterations and their utility in differentiating various cerebrovascular pathologies. Special attention is given to the clinical applications of these imaging techniques for early disease detection, monitoring progression, and guiding therapeutic interventions.

Indexed as

Cerebrovascular DisordersExtracellular FluidExtracellular MatrixNeuroimagingBrainHumansCerebrovascular disordersDisease biomarkersExtracellular matrixExtracellular matrix componentsFluid dynamicsInterstitial fluidNeuroimaging

Identifiers

PMID40210376
PMCPMC11995915

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.